Evidence map›Paper›PMID 32375810›Full record

ArticleJournal of neuroinflammation2020

Integrin CD11b mediates locus coeruleus noradrenergic neurodegeneration in a mouse Parkinson's disease model.

Liyan Hou, Xingyue Qu, Xiaofei Qiu, Ruixue Huang, Xiulan Zhao, Qingshan Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroinflammation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 46 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Liyan HouSchool of Public Health, Dalian Medical University, Dalian, 116044, China.
Xingyue QuDepartment of Clinical Nutrition, Second Affiliated Hospital of Dalian Medical University, Dalian, 116023, China.
Xiaofei QiuQingdao Municipal Center for Disease Control & Prevention/Qingdao Institute of Preventive Medicine, Qingdao, 266033, China.
Ruixue HuangSchool of Public Health, Dalian Medical University, Dalian, 116044, China.
Xiulan ZhaoSchool of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, 250012, China. zhao.xl@sdu.edu.cn.
Qingshan WangSchool of Public Health, Dalian Medical University, Dalian, 116044, China. wangq4@126.com.ORCID http://orcid.org/0000-0003-4115-552X
Dalian Medical University · CNShandong University · CN

Funding

National Natural Science Foundation of China 81973087; 81703264;81872654
6 · The paper itself

Abstract

backgroundThe loss of locus coeruleus noradrenergic (LC/NE) neurons in the brainstem is reported in multiple neurodegenerative disorders, including Parkinson's disease (PD). However, the mechanisms remain unclear. Strong evidence suggested that microglia-mediated neuroinflammation contributes to neurodegeneration in PD. We recently recognized integrin CD11b, the α-chain of macrophage antigen complex-1 (Mac-1, also called CR3), as a key regulator for microglial activation. However, whether CD11b is involved in LC/NE neurodegeneration in PD remains to be investigated.

methodsLC/NE neurodegeneration and microglial activation were compared between wild type (WT) and CD11b KO mice after treated with paraquat and maneb, two pesticides that widely used to create PD model. The role of NLRP3 inflammasome in CD11b-mediated microglial dysfunction and LC/NE neurodegeneration was further explored. LC/NE neurodegeneration, microglial phenotype, and NLRP3 inflammasome activation were determined by using Western blot, immunohistochemistry, and RT-PCR technologies.

resultsParaquat and maneb co-exposure elevated the expressions of CD11b in the brainstem of mice, and CD11b knockout significantly reduced LC/NE neurodegeneration induced by paraquat and maneb. Mitigated microglial activation and gene expressions of proinflammatory cytokines were also observed in paraquat and maneb-treated CD11b

conclusionOur findings suggested that CD11b mediates LC/NE neurodegeneration through NLRP3 inflammation-dependent microglial proinflammatory activation in a two pesticide-induced mouse PD model, providing a novel insight into the immune pathogenesis of LC/NE neuronal damage in related disorders.

Indexed as

Adrenergic NeuronsAnimalsCD11b AntigenDisease Models, AnimalInflammasomesLocus CoeruleusMaleManebMiceMice, Inbred C57BLMice, KnockoutMicrogliaNerve DegenerationNLR Family, Pyrin Domain-Containing 3 ProteinParaquatParkinsonian DisordersCD11b AntigenInflammasomesItgam protein, mouseManebNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseParaquatPesticidesIntegrinMicroglial activationNLRP3 inflammasomeNoradrenergic neurodegenerationOxidative stress

Identifiers

PMID32375810
PMCPMC7201626
OpenAlexW3020966241

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.