Evidence map›Paper›PMID 32375798›Full record

ArticleRadiation oncology (London, England)2020

The effect of hyperbaric oxygen therapy on bone macroscopy, composition and biomechanical properties after ionizing radiation injury.

Luiz Henrique Ferreira Júnior, Pedro Henrique Justino Oliveira Limirio, Priscilla Barbosa Ferreira Soares, Paula Dechichi, Letícia de Souza Castro Filice, Paulo Sérgio Quagliatto, Flaviana Soares Rocha

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiation oncology (London, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Review of the Pathogenesis, Diagnosis, and Management of Osteoradionecrosis of the Femoral Head.Medical science monitor : international medical journal of experimental and clinical research · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Luiz Henrique Ferreira JúniorIntegrated Dental Clinic Program, Faculty of Dentistry, Federal University of Uberlândia, Avenida Pará s/n°, Campus Umuarama, Bloco 4L, Bairro Umuarama, Uberlândia, Minas Gerais, 38.400-902, Brazil.
Pedro Henrique Justino Oliveira LimirioIntegrated Dental Clinic Program, Faculty of Dentistry, Federal University of Uberlândia, Avenida Pará s/n°, Campus Umuarama, Bloco 4L, Bairro Umuarama, Uberlândia, Minas Gerais, 38.400-902, Brazil.
Priscilla Barbosa Ferreira SoaresDepartment of Periodontology and Oral Implantology, Faculty of Dentistry, Federal University of Uberlândia, Avenida Pará s/nº, Campus Umuarama, Bloco 4L, Bairro Umuarama, Uberlândia, Minas Gerais, 38.400-902, Brazil.
Paula DechichiDepartment of Cell Biology, Histology and Embryology, Faculty of Dentistry, Federal University of Uberlândia, Avenida Pará s/nº, Campus Umuarama, Bloco 2B, Bairro Umuarama, Uberlândia, Minas Gerais, 38.400-902, Brazil.
Letícia de Souza Castro FiliceDepartment of Clinical Medicine, Histology and Embryology, Faculty of Medicine, Federal University of Uberlândia, Avenida Pará s/n°, Campus Umuarama, Bloco 4U, Bairro Umuarama, Uberlândia, Minas Gerais, 38.400-902, Brazil.
Paulo Sérgio QuagliattoDepartment of Dentistry and Dental Materials, Faculty of Dentistry, Federal University of Uberlândia, Avenida Pará s/nº, Campus Umuarama, Bloco 2B, Bairro Umuarama, Uberlândia, Minas Gerais, 38.400-902, Brazil.
Flaviana Soares RochaDepartment of Oral and Maxillofacial Surgery and Traumatology and Implantology, Faculty of Dentistry, Federal University of Uberlândia, Avenida Pará s/nº, Campus Umuarama, Bloco 2B, Bairro Umuarama, Uberlândia, Minas Gerais, 38.400-902, Brazil. flavianasoares.rocha@gmail.com.
Universidade Federal de Uberlândia · BR

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 001Fundação de Amparo à Pesquisa do Estado de Minas Gerais APQ-00998-14
6 · The paper itself

Abstract

backgroundRadiotherapy used in tumor treatment compromises vascularization of bone tissue. Hyperbaric oxygenation (HBO) increases oxygen availability and improves vascularization, minimizing the deleterious effects of ionizing radiation (IR). Therefore, the aim of this study was to evaluate HBO therapy effect on bone macroscopy, composition and biomechanical properties after IR damage.

methodsTwenty male Wistar rats weighing 300 ± 20 g (10 weeks of age) were submitted to IR (30 Gy) to the left leg, where the right leg was not irradiated. After 30 days, ten animals were submitted to HBO therapy, which was performed daily for 1 week at 250 kPa for 90-min sessions. All animals were euthanized 37 days after irradiation and the tibia were separated into four groups (n = 10): from animals without HBO - right tibia Non-irradiated (noIRnoHBO) and left tibia Irradiated (IRnoHBO); and from animals with HBO - right tibiae Non-irradiated (noIRHBO) and left tibia Irradiated (IRHBO). The length (proximal-distal) and thickness (anteroposterior and mediolateral) of the tibiae were measured. Biomechanical analysis evaluated flexural strength and stiffness. Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy (ATR-FTIR) was used to calculate the amide I ratio, crystallinity index, and matrix to mineral ratios.

resultsIn the macroscopic and ATR-FTIR analysis, the IRnoHBO showed lower values of length, thickness and amide I ratio, crystallinity index and matrix to mineral ratios compared to noIRnoHBO (p < 0.03). IRnoHBO showed no statistical difference compared to IRHBO for these analyses (p > 0.05). Biomechanics analysis showed that the IRnoHBO group had lower values of flexural strength and stiffness compared to noIRnoHBO and IRHBO groups (p < 0.04). In addition, the noIRHBO group showed higher value of flexural strength when compared to noIRnoHBO and IRHBO groups (p < 0.02).

conclusionsThe present study concluded that IR arrests bone development, decreases the collagen maturation and mineral deposition process, thus reducing the flexural strength and stiffness bone mechanical parameters. Moreover, HBO therapy minimizes deleterious effects of irradiation on flexural strength and the bone stiffness analysis.

Indexed as

Hyperbaric OxygenationAnimalsBiomechanical PhenomenaBone and BonesBone MatrixMaleOsteogenesisRadiation InjuriesRadiation, IonizingRatsRats, WistarTibiaBiomechanical phenomenaBone matrixHyperbaric oxygenationIonizing, radiationOsteogenesisTibia

Identifiers

PMID32375798
PMCPMC7201996
OpenAlexW3020852240

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.