Evidence map›Paper›PMID 32375700›Full record

ArticleBMC geriatrics2020

Sensor-based characterization of daily walking: a new paradigm in pre-frailty/frailty assessment.

Danya Pradeep Kumar, Nima Toosizadeh, Jane Mohler, Hossein Ehsani, Cassidy Mannier, Kaveh Laksari

Registry-linked trialAbstract read
In one paragraph

Article in BMC geriatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01880229 (Phase II and Phase IIB STTR), which is not on this map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01880229 completednot on this map

Phase II and Phase IIB STTR: Portable Device for Telecare Monitoring of Elderly People

Typeobservational_patient_registrySponsorBioSensicsRan2012 to 2018Enrolled180ConditionsFraility, Risk of Falling
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Effects of Remote Exercise on Physical Function in Pre-Frail Older Adults: A Randomized Controlled Trial.Medical science monitor : international medical journal of experimental and clinical research · 2025
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  19. A Sensor-Based mHealth Platform for Remote Monitoring and Intervention of Frailty Patients at Home.International journal of environmental research and public health · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Danya Pradeep KumarDepartment of Biomedical Engineering, University of Arizona, Tucson, AZ, USA.
Nima ToosizadehDepartment of Biomedical Engineering, University of Arizona, Tucson, AZ, USA. ntoosizadeh@aging.arizona.edu.
Jane MohlerDepartment of Biomedical Engineering, University of Arizona, Tucson, AZ, USA.
Hossein EhsaniArizona Center on Aging, Department of Medicine, University of Arizona, Tucson, AZ, USA.
Cassidy MannierDepartment of Biomedical Engineering, University of Arizona, Tucson, AZ, USA.
Kaveh LaksariDepartment of Biomedical Engineering, University of Arizona, Tucson, AZ, USA.

Funding

Phase II STTR: Portable Device for Telecare Monitoring of Elderly PeopleR42AG032748 · NIA · BIOSENSICS, LLC · PI GWIN, JOSEPH T, MOHLER, MARTHA JANE · 2012 to 2016
$2.7M
NIA NIH HHS 2R42AG032748NIA NIH HHS R42 AG032748
6 · The paper itself

Abstract

backgroundFrailty is a highly recognized geriatric syndrome resulting in decline in reserve across multiple physiological systems. Impaired physical function is one of the major indicators of frailty. The goal of this study was to evaluate an algorithm that discriminates between frailty groups (non-frail and pre-frail/frail) based on gait performance parameters derived from unsupervised daily physical activity (DPA).

methodsDPA was acquired for 48 h from older adults (≥65 years) using a tri-axial accelerometer motion-sensor. Continuous bouts of walking for 20s, 30s, 40s, 50s and 60s without pauses were identified from acceleration data. These were then used to extract qualitative measures (gait variability, gait asymmetry, and gait irregularity) and quantitative measures (total continuous walking duration and maximum number of continuous steps) to characterize gait performance. Association between frailty and gait performance parameters was assessed using multinomial logistic models with frailty as the dependent variable, and gait performance parameters along with demographic parameters as independent variables.

resultsOne hundred twenty-six older adults (44 non-frail, 60 pre-frail, and 22 frail, based on the Fried index) were recruited. Step- and stride-times, frequency domain gait variability, and continuous walking quantitative measures were significantly different between non-frail and pre-frail/frail groups (p < 0.05). Among the five different durations (20s, 30s, 40s, 50s and 60s), gait performance parameters extracted from 60s continuous walks provided the best frailty assessment results. Using the 60s gait performance parameters in the logistic model, pre-frail/frail group (vs. non-frail) was identified with 76.8% sensitivity and 80% specificity. DISCUSSION: Everyday walking characteristics were found to be associated with frailty. Along with quantitative measures of physical activity, qualitative measures are critical elements representing the early stages of frailty. In-home gait assessment offers an opportunity to screen for and monitor frailty.

trial registrationThe clinical trial was retrospectively registered on June 18th, 2013 with ClinicalTrials.gov, identifier NCT01880229.

Indexed as

FrailtyAgedFrail ElderlyGaitGeriatric AssessmentHumansWalkingContinuous walkingDaily physical activityFrailtyPerformance parametersWearable sensors

Identifiers

PMID32375700
PMCPMC7203790

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.