Evidence map›Paper›PMID 32375686›Full record

ArticleBMC cancer2020

Integrated analysis of genome-wide miRNAs and targeted gene expression in esophageal squamous cell carcinoma (ESCC) and relation to prognosis.

Howard Yang, Hua Su, Nan Hu, Chaoyu Wang, Lemin Wang, Carol Giffen, Alisa M Goldstein, Maxwell P Lee, Philip R Taylor

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 2 pooled it
4.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 66 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Howard YangCenter for Cancer Research, NCI, Bethesda, MD, 20892, USA.
Hua SuLeidos Biomedical Research, Inc., Frederick, MD, 21702-1201, USA.
Nan HuDivision of Cancer Epidemiology and Genetics, NCI, Bethesda, MD, 20892, USA.
Chaoyu WangCenter for Cancer Research, NCI, Bethesda, MD, 20892, USA.
Lemin WangLeidos Biomedical Research, Inc., Frederick, MD, 21702-1201, USA.
Carol GiffenInformation Management Services, Inc, Calverton, MD, 20705, USA.
Alisa M GoldsteinDivision of Cancer Epidemiology and Genetics, NCI, Bethesda, MD, 20892, USA.
Maxwell P LeeCenter for Cancer Research, NCI, Bethesda, MD, 20892, USA.
Philip R TaylorDivision of Cancer Epidemiology and Genetics, NCI, Bethesda, MD, 20892, USA. ptaylor@mail.nih.gov.
Center for Cancer Research · USDivision of Cancer Epidemiology and GeneticsLeidos (United States) · USInformation Management Services · US

Funding

Integrated analyses of genetics, epigenetics, and gene expressionZIHBC011703 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI LEE, MAXWELL · 2016 to 2025
$10.9M
Nutrition Intervention Trials in Linxian ChinaZIACP000112 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI ABNET, CHRISTIAN · 2009 to 2025
$8.2M
6 · The paper itself

Abstract

backgroundEsophageal squamous cell carcinoma (ESCC) is a leading cause of cancer death worldwide and in China. We know miRNAs influence gene expression in tumorigenesis, but it is unclear how miRNAs affect gene expression or influence survival at the genome-wide level in ESCC.

methodsWe performed miRNA and mRNA expression arrays in 113 ESCC cases with tumor/normal matched tissues to identify dysregulated miRNAs, to correlate miRNA and mRNA expressions, and to relate miRNA and mRNA expression changes to survival and clinical characteristics.

resultsThirty-nine miRNAs were identified whose tumor/normal tissue expression ratios showed dysregulation (28 down- and 11 up-regulated by at least two-fold with P < 1.92E-04), including several not previously reported in ESCC (miR-885-5p, miR-140-3p, miR-708, miR-639, miR-596). Expressions of 16 miRNAs were highly correlated with expressions of 195 genes (P < 8.42E-09; absolute rho values 0.51-0.64). Increased expressions of miRNA in tumor tissue for both miR-30e* and miR-124 were associated with increased survival (P < 0.05). Similarly, nine probes in eight of 818 dysregulated genes had RNA expression levels that were nominally associated with survival, including NF1, ASXL1, HSPA4, TGOLN2, BAIAP2, EZH2, CHAF1A, SUPT7L.

conclusionsOur characterization and integrated analysis of genome-wide miRNA and gene expression in ESCC provides insights into the expression of miRNAs and their relation to regulation of RNA targets in ESCC tumorigenesis, and suggest opportunities for the future development of miRs and mRNAs as biomarkers for early detection, diagnosis, and prognosis in ESCC.

Indexed as

Gene Expression Regulation, NeoplasticGenome, HumanAdultAgedBiomarkers, TumorCase-Control StudiesEsophageal NeoplasmsEsophageal Squamous Cell CarcinomaFemaleFollow-Up StudiesGene Expression ProfilingHumansMaleMicroRNAsMiddle AgedPrognosisBiomarkers, TumorMicroRNAsRNA, MessengerEsophageal squamous cell carcinomamicroRNAsmRNAsPrognosis

Identifiers

PMID32375686
PMCPMC7201714
OpenAlexW3020891899

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.