ArticleBMC nephrology2020
Gait speed and handgrip strength as predictors of all-cause mortality and cardiovascular events in hemodialysis patients.
Article in BMC nephrology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 6 of them syntheses that pooled it.
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Who cites it
45 citing papers in PubMed, 6 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- Gait Speed and All-Cause Mortality in Whole-Spectrum Chronic Kidney Disease: A Systematic Review and Meta-Analysis Included 6217 Participants.Journal of cachexia, sarcopenia and muscle · 2025Pooled it
- Thresholds of handgrip strength for all-cause mortality in patients with chronic kidney disease: a secondary systematic review with dose-response meta-analysis.Renal failure · 2024Pooled it
- Handgrip strength and all-cause mortality in patients with chronic kidney disease: an updated systematic review and meta-analysis of cohort studies.International urology and nephrology · 2023Pooled it
- Physical function and all-cause mortality in patients with chronic kidney disease and end-stage renal disease: a systematic review and meta-analysis.International urology and nephrology · 2023Pooled it
- Pooled it
- Exercise interventions improve depression and anxiety in chronic kidney disease patients: a systematic review and meta-analysis.International urology and nephrology · 2021Pooled it
- Electroacupuncture Treatment on Sarcopenia in Patients Undergoing Maintenance Haemodialysis: An Effective Therapy.Journal of cachexia, sarcopenia and muscle · 2026Trial
- Intradialytic Exercise: Effects on Arterial Stiffness and Gait Speed in Patients Undergoing Hemodialysis.Medical science monitor : international medical journal of experimental and clinical research · 2025Trial
- Twelve weeks of combined physical and cognitive intradialytic training preserves alertness and improves gait speed: a randomized controlled trial.Aging clinical and experimental research · 2023Trial
- Game-based intradialytic non-weight-bearing exercise training on gait speed and balance in older adults with diabetes: a single-blind randomized controlled trial.Scientific reports · 2023Trial
- The effects of short bouts of ergometric exercise for severely burned children in intensive care: A randomized controlled trial.Clinical rehabilitation · 2022Trial
- Associations of gait speed, grip strength, depressive symptoms, and their combinations with fracture risk in older adults.GeroScience · 2026Article
- The prognostic value of gait speed in hemodialysis patients: A prospective observational study.PloS one · 2026Observational
- Impact of Annual Dry Weight Changes on Mortality and Cardiovascular Outcomes in Patients Undergoing Haemodialysis.Journal of cachexia, sarcopenia and muscle · 2025Article
- Fibroblast Growth Factor 23 and Sarcopenia in Maintenance Haemodialysis Population.Journal of cachexia, sarcopenia and muscle · 2025Article
- Handgrip strength and menopause are associated with cardiovascular risk in women with obesity: a cross-sectional study.BMC women's health · 2025Article
- Comprehensive Insights into Sarcopenia in Dialysis Patients: Mechanisms, Assessment, and Therapeutic Approaches.Medicina (Kaunas, Lithuania) · 2025Review
- The 6-Minute Pegboard and Ring Test (6PBRT) for Evaluation of Upper Limbs Functional Capacity in Hemodialysis Patients: A Validation Study.Physiotherapy Canada. Physiotherapie Canada · 2025Article
- Prediction of future aging-related slow gait and its determinants with deep learning and logistic regression.PloS one · 2025Article
- A Nomogram for Predicting the Risk of Death in Patients with Prolonged Hospital Stays in Internal Medicine Wards: A Retrospective Study.International journal of general medicine · 2025Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLow physical performance in patients undergoing maintenance hemodialysis is associated with a high mortality rate. We investigated the clinical relevance of gait speed and handgrip strength, the two most commonly used methods of assessing physical performance.
methodsWe obtained data regarding gait speed and handgrip strength from 277 hemodialysis patients and evaluated their relationships with baseline parameters, mental health, plasma inflammatory markers, and major adverse clinical outcomes. Low physical performance was defined by the recommendations suggested by the Asian Working Group on Sarcopenia.
resultsThe prevalence of low gait speed and handgrip strength was 28.2 and 44.8%, respectively. Old age, low serum albumin levels, high comorbidity index score, and impaired cognitive functions were associated with low physical performance. Patients with isolated low gait speed exhibited a general trend for worse quality of life than those with isolated low handgrip strength. Gait speed and handgrip strength showed very weak correlations with different determining factors (older age, the presence of diabetes, and lower serum albumin level for low gait speed, and lower body mass index and the presence of previous cardiovascular events for low handgrip strength). Patients with low gait speed and handgrip strength had elevated levels of plasma endocan and matrix metalloproteinase-7 and the highest risks for all-cause mortality and cardiovascular events among the groups (adjusted hazard ratio of 2.72, p = 0.024). Elderly patients with low gait speed and handgrip strength were at the highest risk for poor clinical outcomes.
conclusionGait speed and handgrip strength reflected distinctive aspects of patient characteristics and the use of both factors improved the prediction of adverse clinical outcomes in hemodialysis patients. Gait speed seems to be a better indicator of poor patient outcomes than is handgrip strength.
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Registered trials
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