Observational studyBMC gastroenterology2020
Lead poisoning; a neglected potential diagnosis in abdominal pain.
Observational study in BMC gastroenterology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 53 citations in OpenAlex.
- Intravenous calcium Gluconate alleviates Lead-induced abdominal pain, a randomized clinical trial.BMC pharmacology & toxicology · 2020Trial
- A type 2 diabetes patient with three years of persistent abdominal pain: the culprit was variegate porphyria-a case report.Frontiers in endocrinology · 2026Article
- Lead-Induced Nephrotoxicity and Its Therapeutic Interventions: An Updated Review.Biological trace element research · 2026Review
- A mixed-method scoping review examining parental perspectives on heavy metal exposure in children.BMC public health · 2025Article
- Association between blood lead levels and constipation in adults: insights from NHANES data (2005-2010).BMC gastroenterology · 2025Article
- Regional concentrations of heavy metals in surface soils and risk of body pain in elderly residential population: a national cohort study in China.BMC public health · 2025Article
- Modulation of Blood Lead Level and Liver Function Tests in Iranian Opium Users.International journal of preventive medicine · 2025Article
- Analysis of serum lead, copper, iron, and zinc and hematological parameters in battery smelting workers: assessing lead toxicity.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2024Article
- Molecular and Environmental Determinants of Addictive Substances.Biomolecules · 2024Review
- Unmasking herbal medication-induced lead poisoning in a geriatric patient with gastrointestinal symptoms.BMJ case reports · 2023Article
- Automated lead toxicity prediction using computational modelling framework.Health information science and systems · 2023Article
- Gastrointestinal Manifestations of Lead Poisoning: A Brief Report.Iranian journal of medical sciences · 2023Article
- Article
- A rare case report of lead encephalopathy due to high blood lead level.Clinical case reports · 2023Article
- Clinical-Pathological Conference Series from the Medical University of Graz : Case No 175: A 54-year-old man with hyponatremia and delirium after surgery for a prolapsed disc.Wiener klinische Wochenschrift · 2023Article
- Blood lead level evaluation in children presenting with chronic constipation in Tehran-Iran: a cross-sectional study.Scientific reports · 2023Article
- Asymptomatic Lead Poisoning in a Pediatric Patient.Cureus · 2023Article
- Comparison of Blood Lead Levels in Children and Adolescents with and without Functional Abdominal Pain.Advanced biomedical research · 2023Article
- Antidotal and protective effects of mangosteen (Iranian journal of basic medical sciences · 2023Review
- Clinical-Pathological Conference Series from the Medical University of Graz : Case No 125: A 42-year-old man with loss of appetite, vomiting and stabbing abdominal pain.Wiener klinische Wochenschrift · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundAbdominal pain may be a presenting symptom of lead poisoning and is often difficult to diagnose. This study aimed to determine the prevalence of abdominal pain in patients seen in the Laghman Hakim Hospital ED and GI clinic who were lead-intoxicated, with or without opiate use disorder.
methodsBetween July 2017 and January 2018, patients seen in the ED and GI clinic of Loghman Hakim Hospital with unexplained abdominal pain or abdominal pain resistant to treatment were enrolled. Informed consent was obtained from potential enrollees. For standardization, a pre-designed data collection tool was developed for uniform data acquisition. Opiate use was determined historically. For this study, lead poisoning was defined as a blood lead level (BLL) greater than or equal to 30 μg/dL (1.45 μmol/L) with concomitant GI symptoms.
resultsOf 125 patients admitted, 28 (22.4%) had BLLs higher than 30 μg/dL. None of the patients had signs and symptoms of opioid withdrawal syndrome during evaluation. Elevated BLLs were significantly correlated with oral opium use/abuse, history of addiction for over the preceding 12 years. The daily opium use was more than 2.75 g. There was a statistical correlation between lead toxicity and abdominal pain consistency and intensity, constipation, and paresthesias. Anemia, leukocytosis, and abnormal liver enzyme tests were laboratory findings associated with lead toxicity. Four patients died, one of whom was diagnosed with lead toxicity.
conclusionLead toxicity should be considered in the potential differential diagnosis of severe and resistant abdominal pain in patients referring to general EDs or GI clinics if a positive history of opium abuse exists.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.