Evidence map›Paper›PMID 32375566›Full record

ArticleTissue engineering. Part A2020

Evaluation of Autologously Derived Biomaterials and Stem Cells for Bone Tissue Engineering.

Paiyz E Mikael, Aleksandra A Golebiowska, Sangamesh G Kumbar, Syam P Nukavarapu

Abstract read
In one paragraph

Article in Tissue engineering. Part A, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Paiyz E MikaelDepartment of Materials Science and Engineering, University of Connecticut, Storrs, Connecticut, USA.
Aleksandra A GolebiowskaDepartment of Biomedical Engineering, University of Connecticut, Storrs, Connecticut, USA.
Sangamesh G KumbarDepartment of Materials Science and Engineering, University of Connecticut, Storrs, Connecticut, USA.
Syam P NukavarapuDepartment of Materials Science and Engineering, University of Connecticut, Storrs, Connecticut, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite progress, clinical translation of tissue engineering (TE) products/technologies is limited. A significant effort is underway to develop biomaterials and cells through a minimally modified process for clinical translation of TE products. Recently, bone marrow aspirate (BMA) was identified as an autologous source of cells for TE applications and is currently being tested in clinical therapies, but the isolation methods need improvement to avoid potential for contamination and increase progenitor cell yield. To address these issues, we reproducibly processed human peripheral blood (PB) and BMA to develop autologously derived biomaterials and cells. We demonstrated PB-derived biomaterial/gel cross-linking and fibrin gel formation with varied gelation times as well as biocompatibility through support of human bone marrow-derived stem cell survival and growth

Indexed as

Biocompatible MaterialsBone and BonesMesenchymal Stem CellsTissue EngineeringAdultCell DifferentiationCells, CulturedFemaleHumansMaleMiddle AgedYoung AdultBiocompatible Materialsbed side TEBMACD146+/CD271+ cellsclinical translationconcentrated BMAfibrinintra-operative strategyminimally modified tissueperipheral blood

Identifiers

PMID32375566
PMCPMC7580602

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.