ArticleArteriosclerosis, thrombosis, and vascular biology2020
Dysregulation of FOXO1 (Forkhead Box O1 Protein) Drives Calcification in Arterial Calcification due to Deficiency of CD73 and Is Present in Peripheral Artery Disease.
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Article in Arteriosclerosis, thrombosis, and vascular biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32citing papers in PubMed
3.8field-weighted citation impact, top 5% of its field
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32 citing papers in PubMed, 47 citations in OpenAlex.
- Pilot study to evaluate the safety and effectiveness of etidronate treatment for arterial calcification due to deficiency of CD73 (ACDC).Vascular medicine (London, England) · 2024Trial
- Peripheral Vascular Calcification.Arteriosclerosis, thrombosis, and vascular biology · 2026Review
- Medial arterial calcification in ageing and disease: current evidence and knowledge gaps.European heart journal · 2025Review
- Decoding the regulatory role of noncoding RNAs in biological and vascular calcification.Molecular biology reports · 2025Review
- Phosphate in Physiological and Pathological Mineralization: Important yet Often Unheeded.MedComm · 2025Review
- Rapamycin reduces mineral density and promotes beneficial vascular remodeling in a murine model of severe medial arterial calcification.American journal of physiology. Heart and circulatory physiology · 2025Article
- Rapamycin Reduces Mineral Density and Promotes Beneficial Vascular Remodeling in a Murine Model of Severe Medial Arterial Calcification.bioRxiv : the preprint server for biology · 2025Article
- Non-Canonical TERT Activity Initiates Osteogenesis in Calcific Aortic Valve Disease.Circulation research · 2025Article
- Metabolites and metabolism in vascular calcification: links between adenosine signaling and the methionine cycle.American journal of physiology. Heart and circulatory physiology · 2024Review
- FOXO1 regulates RUNX2 ubiquitination through SMURF2 in calcific aortic valve disease.Redox biology · 2024Article
- Peripheral Artery Disease: Molecular Mechanisms and Novel Therapies.Arteriosclerosis, thrombosis, and vascular biology · 2024Review
- Aging Two-Step: SOX9's Influence on Vascular Stiffness and Senescence.Circulation research · 2024Article
- The Purinergic Nature of Pseudoxanthoma Elasticum.Biology · 2024Review
- A new perspective on intervertebral disc calcification-from bench to bedside.Bone research · 2024Review
- Inborn Errors of Purine Salvage and Catabolism.Metabolites · 2023Review
- Role of the extracellular ATP/pyrophosphate metabolism cycle in vascular calcification.Purinergic signalling · 2023Review
- Circulating Ectonucleotidases Signal Impaired Myocardial Perfusion at Rest and Stress.Journal of the American Heart Association · 2023Article
- Imaging findings of arterial calcification due to deficiency of CD73: A case study.Journal of radiology case reports · 2023Article
- Hydrogel delivery of purinergic enzymes improves cardiac ischemia/reperfusion injury.Journal of molecular and cellular cardiology · 2023Article
- Ecto-5'-nucleotidase (Nt5e/CD73)-mediated adenosine signaling attenuates TGFβ-2 induced elastin and cellular contraction.American journal of physiology. Cell physiology · 2023Article
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Authors and funding
14 authors at 4 institutions in 1 country.
William J Moorhead *From the Department of Medicine, Division of Cardiology, University of Pittsburgh, PA (W.J.M., C.C.C., R.A.C., J.C., R.W., C.R., C.K.B., S.S., M.L., D.G., C.S.H.).
Claire C Chu *From the Department of Medicine, Division of Cardiology, University of Pittsburgh, PA (W.J.M., C.C.C., R.A.C., J.C., R.W., C.R., C.K.B., S.S., M.L., D.G., C.S.H.).
Rolando A CuevasFrom the Department of Medicine, Division of Cardiology, University of Pittsburgh, PA (W.J.M., C.C.C., R.A.C., J.C., R.W., C.R., C.K.B., S.S., M.L., D.G., C.S.H.).
Jack CallahanFrom the Department of Medicine, Division of Cardiology, University of Pittsburgh, PA (W.J.M., C.C.C., R.A.C., J.C., R.W., C.R., C.K.B., S.S., M.L., D.G., C.S.H.).
Ryan WongFrom the Department of Medicine, Division of Cardiology, University of Pittsburgh, PA (W.J.M., C.C.C., R.A.C., J.C., R.W., C.R., C.K.B., S.S., M.L., D.G., C.S.H.).
Cailyn ReganFrom the Department of Medicine, Division of Cardiology, University of Pittsburgh, PA (W.J.M., C.C.C., R.A.C., J.C., R.W., C.R., C.K.B., S.S., M.L., D.G., C.S.H.).
Camille K BouffordFrom the Department of Medicine, Division of Cardiology, University of Pittsburgh, PA (W.J.M., C.C.C., R.A.C., J.C., R.W., C.R., C.K.B., S.S., M.L., D.G., C.S.H.).
Swastika SurFrom the Department of Medicine, Division of Cardiology, University of Pittsburgh, PA (W.J.M., C.C.C., R.A.C., J.C., R.W., C.R., C.K.B., S.S., M.L., D.G., C.S.H.).
Mingjun LiuFrom the Department of Medicine, Division of Cardiology, University of Pittsburgh, PA (W.J.M., C.C.C., R.A.C., J.C., R.W., C.R., C.K.B., S.S., M.L., D.G., C.S.H.).
Delphine GomezFrom the Department of Medicine, Division of Cardiology, University of Pittsburgh, PA (W.J.M., C.C.C., R.A.C., J.C., R.W., C.R., C.K.B., S.S., M.L., D.G., C.S.H.).
Jason N MacTaggartDepartment of Surgery, University of Nebraska Medical Center, Omaha (J.N.M.).
Alexey KamenskiyDepartment of Biomechanics, University of Nebraska Omaha (A.K.).
Manfred BoehmLaboratory of Cardiovascular Regenerative Medicine, National Heart, Lung, and Blood Institute, Bethesda, MD (M.B.).
Cynthia St HilaireFrom the Department of Medicine, Division of Cardiology, University of Pittsburgh, PA (W.J.M., C.C.C., R.A.C., J.C., R.W., C.R., C.K.B., S.S., M.L., D.G., C.S.H.).
University of Pittsburgh · USNational Heart Lung and Blood Institute · USUniversity of Nebraska at Omaha · USUniversity of Nebraska Medical Center · US
Funding
Optimized Stents for the Femoropopliteal ArteryR01HL125736 · NHLBI · UNIVERSITY OF NEBRASKA OMAHA · PI KAMENSKIY, ALEXEY, MACTAGGART, JASON · 2015 to 2024
$6.3MEffects of aortic compliance and Windkessel reduction on cardiac and aortic pathophysiologyR01HL147128 · NHLBI · UNIVERSITY OF NEBRASKA OMAHA · PI DESYATOVA, ANASTASIA S · 2019 to 2023
$3.0MRegulation of Vascular Calcification by Adenosine SignalingK22HL117917 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ST. HILAIRE, CYNTHIA · 2015 to 2017
$731kNHLBI NIH HHS K22 HL117917NHLBI NIH HHS R01 HL125736NHLBI NIH HHS R01 HL147128
Abstract
objectiveThe recessive disease arterial calcification due to deficiency of CD73 (ACDC) presents with extensive nonatherosclerotic medial layer calcification in lower extremity arteries. Lack of CD73 induces a concomitant increase in TNAP (tissue nonspecific alkaline phosphatase;
conclusionsThese data show that lack of CD73-mediated cAMP signaling promotes expression of the human
Indexed as
5'-NucleotidaseAdultAgedAged, 80 and overAlkaline PhosphataseAutophagyCase-Control StudiesCells, CulturedFemaleFibroblastsForkhead Box Protein O1GPI-Linked ProteinsHumansMaleMiddle AgedPeripheral Arterial Disease5'-NucleotidaseAlkaline PhosphataseALPL protein, humanForkhead Box Protein O1FOXO1 protein, humanGPI-Linked ProteinsMTOR protein, humanNT5E protein, humanProto-Oncogene Proteins c-aktTOR Serine-Threonine Kinasesalkaline phosphatasearteriescalcificationlower extremity
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.