ArticleJournal of clinical medicine2020
Consciousness and the Dimensionality of DOC Patients via the Generalized Ising Model.
Article in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A methodological guideline for consciousness assessment via neural electrophysiological activity.Military Medical Research · 2025Guideline
- Personalized whole-brain Ising models with heterogeneous nodes capture differences among brain regions.bioRxiv : the preprint server for biology · 2026Article
- Spontaneous Brain Activity Emerges from Pairwise Interactions in the Larval Zebrafish Brain.Physical review. X · 2024Article
- Investigating structural and functional aspects of the brain's criticality in stroke.Scientific reports · 2023Article
- Computational modelling in disorders of consciousness: Closing the gap towards personalised models for restoring consciousness.NeuroImage · 2023Article
- A scoping review for building a criticality-based conceptual framework of altered states of consciousness.Frontiers in systems neuroscience · 2023Article
- Article
- An innovative approach for the evaluation of prolonged disorders of consciousness using NF-L and GFAP biomarkers: a pivotal study.Scientific reports · 2022Article
- Whole-brain modelling identifies distinct but convergent paths to unconsciousness in anaesthesia and disorders of consciousness.Communications biology · 2022Article
- Self-organized criticality as a framework for consciousness: A review study.Frontiers in psychology · 2022Article
- Consciousness and complexity: a consilience of evidence.Neuroscience of consciousness · 2021Review
- Whole-Brain Models to Explore Altered States of Consciousness from the Bottom Up.Brain sciences · 2020Review
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
The data from patients with severe brain injuries show complex brain functions. Due to the difficulties associated with these complex data, computational modeling is an especially useful tool to examine the structure-function relationship in these populations. By using computational modeling for patients with a disorder of consciousness (DoC), not only we can understand the changes of information transfer, but we also can test changes to different states of consciousness by hypothetically changing the anatomical structure. The generalized Ising model (GIM), which specializes in using structural connectivity to simulate functional connectivity, has been proven to effectively capture the relationship between anatomical structures and the spontaneous fluctuations of healthy controls (HCs). In the present study we implemented the GIM in 25 HCs as well as in 13 DoC patients diagnosed at three different states of consciousness. Simulated data were analyzed and the criticality and dimensionality were calculated for both groups; together, those values capture the level of information transfer in the brain. Ratifying previous studies, criticality was observed in simulations of HCs. We were also able to observe criticality for DoC patients, concluding that the GIM is generalizable for DoC patients. Furthermore, dimensionality increased for the DoC group as compared to healthy controls, and could distinguish different diagnostic groups of DoC patients.
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