Evidence map›Paper›PMID 32375361›Full record

ReviewInternational journal of molecular sciences2020

MicroRNA Nanotherapeutics for Lung Targeting. Insights into Pulmonary Hypertension.

Susana Carregal-Romero, Lucía Fadón, Edurne Berra, Jesús Ruíz-Cabello

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Nebulization of extracellular vesicles: A promising small RNA delivery approach for lung diseases.Journal of controlled release : official journal of the Controlled Release Society · 2022
    Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Genetic Delivery and Gene Therapy in Pulmonary Hypertension.International journal of molecular sciences · 2021
    Review
  9. Emerging therapies for right ventricular dysfunction and failure.Cardiovascular diagnosis and therapy · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Susana Carregal-RomeroCenter for Cooperative Research in Biomaterials (CIC biomaGUNE), Basque Research and Technology Alliance (BRTA), Paseo de Miramón 182, 20014 San Sebastián, Spain.ORCID 0000-0003-1444-6268
Lucía FadónCenter for Cooperative Research in Biomaterials (CIC biomaGUNE), Basque Research and Technology Alliance (BRTA), Paseo de Miramón 182, 20014 San Sebastián, Spain.
Edurne BerraCenter for Cooperative Research in Bioscience (CIC bioGUNE), Buiding 800, Science and Technology Park of Bizkaia, 48160 Derio, Spain.
Jesús Ruíz-CabelloCenter for Cooperative Research in Biomaterials (CIC biomaGUNE), Basque Research and Technology Alliance (BRTA), Paseo de Miramón 182, 20014 San Sebastián, Spain.ORCID 0000-0001-8681-5056

Funding

Ekonomiaren Garapen eta Lehiakortasun Saila, Eusko Jaurlaritza KK-2019/bmG19Ministerio de Ciencia y Tecnología MDM-2017-0720Ministerio de Economía y Competitividad SAF2017-84494-C2-R
6 · The paper itself

Abstract

In this review, the potential future role of microRNA-based therapies and their specific application in lung diseases is reported with special attention to pulmonary hypertension. Current limitations of these therapies will be pointed out in order to address the challenges that they need to face to reach clinical applications. In this context, the encapsulation of microRNA-based therapies in nanovectors has shown improvements as compared to chemically modified microRNAs toward enhanced stability, efficacy, reduced side effects, and local administration. All these concepts will contextualize in this review the recent achievements and expectations reported for the treatment of pulmonary hypertension.

Indexed as

RNAi TherapeuticsTheranostic NanomedicineAnimalsBiomarkersDrug Delivery SystemsHumansHypertension, PulmonaryLungLung DiseasesMicroRNAsNanomedicineNanotechnologyOligonucleotides, AntisenseRNA, UntranslatedBiomarkersMicroRNAsOligonucleotides, AntisenseRNA, Untranslatedantisense-mediated inhibitionliposomelung targetingmicroRNAmimicRNAnanoparticlenon-coding RNApulmonary diseasepulmonary hypertensionreplacement therapy

Identifiers

PMID32375361
PMCPMC7246754

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.