Evidence map›Paper›PMID 32375358›Full record

ArticleInternational journal of environmental research and public health2020

The Italian External Quality Assessment Program for Cystic Fibrosis Sweat Chloride Test: Does Active Participation Improve the Quality?

Marco Salvatore, Annalisa Amato, Giovanna Floridia, Federica Censi, Gianluca Ferrari, Fabrizio Tosto, Rita Padoan, Valeria Raia, Natalia Cirilli, Giuseppe Castaldo and 4 more

Abstract read
In one paragraph

Article in International journal of environmental research and public health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Marco SalvatoreUndiagnosed Rare Diseases Interdepartmental Unit, Istituto Superiore di Sanità, National Center Rare Diseases, 00161 Rome, Italy.
Annalisa AmatoUndiagnosed Rare Diseases Interdepartmental Unit, Istituto Superiore di Sanità, National Center Rare Diseases, 00161 Rome, Italy.
Giovanna FloridiaUnità di Bioetica, Istituto Superiore di Sanità, 00161 Roma, Italia.ORCID 0000-0003-4187-8816
Federica CensiUndiagnosed Rare Diseases Interdepartmental Unit, Istituto Superiore di Sanità, National Center Rare Diseases, 00161 Rome, Italy.
Gianluca FerrariUndiagnosed Rare Diseases Interdepartmental Unit, Istituto Superiore di Sanità, National Center Rare Diseases, 00161 Rome, Italy.
Fabrizio TostoUndiagnosed Rare Diseases Interdepartmental Unit, Istituto Superiore di Sanità, National Center Rare Diseases, 00161 Rome, Italy.
Rita PadoanCentro di Supporto Fibrosi Cistica, Dipartimento Pediatrico, Università di Brescia, ASST Spedali Civili, 25123 Brescia, Italia.ORCID 0000-0002-0624-8125
Valeria RaiaCentro Regionale Fibrosi Cistica, Unità di Pediatria, Dipartimento di Scienze Mediche Traslazionali, Università degli Studi di Napoli, Federico II, 80145 Napoli, Italia.
Natalia CirilliCentro di Riferimento Fibrosi Cistica, Dipartimento Materno Infantile, AOU Ospedali Riuniti, 60121 Ancona, Italia.
Giuseppe CastaldoDipartimento di Medicina Molecolare e Biotecnologie Mediche, Università di Napoli Federico II; CEINGE-Biotecnologie avanzate, scarl, 80131 Napoli, Italia.
Ettore CapoluongoDipartimento di Medicina Molecolare e Biotecnologie Mediche, Università di Napoli Federico II; CEINGE-Biotecnologie avanzate, scarl, 80131 Napoli, Italia.
Ubaldo CarusoLABSIEM-Laboratorio per lo Studio degli Errori Congeniti del Metabolismo, Università degli Studi di Genova-DINOGMI, 16132 Genova, Italia.
Carlo CorbettaSC Laboratorio di Riferimento Regionale per lo Screening Neonatale-Regione Lombardia, ASST Fatebenefratelli Sacco, 20157 Milano, Italia.
Domenica TaruscioUndiagnosed Rare Diseases Interdepartmental Unit, Istituto Superiore di Sanità, National Center Rare Diseases, 00161 Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

(1) Background: Diagnostic testing for cystic fibrosis (CF) is based on a sweat chloride test (SCT) considering the appropriate signs and symptoms of the disease and results of a gene mutation analysis. In 2014, the Istituto Superiore di Sanità (ISS) established a pilot Italian external quality assessment program for CF SCT (Italian EQA-SCT), which is now a third party service carried out by the ISS. (2) Methods: The ongoing scheme is prospective, enrollment is voluntary, and the payment of a fee is required. Results are shared through a dedicated web-facility. Assessment covers the analysis, interpretation, and reporting of results. (3) Results: Thirteen, fifteen, sixteen, and fifteen different laboratories, respectively, participated from 2015 to 2016 and from 2018 to 2019 in the Italian EQA-SCT scheme. Eleven different laboratories participated each year in all four rounds of the Italian EQA-SCT. (4) Conclusions: The overall results obtained from the laboratories participating constantly clearly show that their qualitative and quantitative performance improved significantly. This is due to the opportunity-after receiving the EQA results-to constantly review their performance and address any inconsistencies. We firmly believe that participation in the EQA program will improve the quality of participating laboratories and that EQA participation should become mandatory as a fundamental requirement for laboratory accreditation.

Indexed as

Cystic FibrosisSweatChloridesHumansItalyProspective StudiesQuality Assurance, Health CareChloridesactive participationcholoridecystic fibrosisdiagnosisexternal quality assessmentqualitysweat test

Identifiers

PMID32375358
PMCPMC7246827

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.