ReviewJournal of clinical medicine2020
Eating Disorders, Heredity and Environmental Activation: Getting Epigenetic Concepts into Practice.
Review in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Epigenetic alterations in patients with anorexia nervosa-a systematic review.Molecular psychiatry · 2024Pooled it
- Recovery From Anorexia Nervosa: A Concept Analysis.Journal of advanced nursing · 2026Review
- Dysregulation of neurodevelopmental regulatory networks in Anorexia Nervosa: an integrated multi-layered omics analysis.Frontiers in cell and developmental biology · 2026Article
- Predicting adolescent disordered eating and behaviours: exploring environmental moderators of polygenic risk.Journal of child psychology and psychiatry, and allied disciplines · 2025Article
- Genetic and Genomic Literacy of Healthcare Providers Treating Anorexia Nervosa in the United States: A Mixed Methods, Cross-Sectional Study.Brain and behavior · 2025Article
- Application of Genetic Testing for Anorexia Nervosa: An Ethical Analysis.Brain and behavior · 2025Article
- Article
- Anorexia nervosa in children and adolescents: an early detection of risk factors.Italian journal of pediatrics · 2024Article
- New understandings meet old treatments: putting a contemporary face on established protocols.Journal of eating disorders · 2024Article
- Article
- Article
- Similarities and differences regarding acute anorexia nervosa and semi-starvation: does behavioral thermoregulation play a central role?Frontiers in behavioral neuroscience · 2023Article
- Mechanisms by which adverse childhood experiences, other traumas and PTSD influence the health and well-being of individuals with eating disorders throughout the life span.Journal of eating disorders · 2022Review
- A critical analysis of eating disorders and the gut microbiome.Journal of eating disorders · 2022Article
- Genome-wide DNA methylation profiling in anorexia nervosa discordant identical twins.Translational psychiatry · 2022Article
- Article
- Meta-analysis of structural MRI studies in anorexia nervosa and the role of recovery: a systematic review protocol.Systematic reviews · 2021Article
- Fatigue, Stress, and Functional Status are Associated With Taste Changes in Oncology Patients Receiving Chemotherapy.Journal of pain and symptom management · 2021Article
- Individuals Diagnosed with Binge-Eating Disorder Have DNA Hypomethylated Sites in Genes of the Metabolic System: A Pilot Study.Nutrients · 2021Article
- Advances in Eating Disorders.Journal of clinical medicine · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Epigenetic mechanisms are believed to link environmental exposures to alterations in gene expression, and in so doing, to provide a physical substrate for the activation of hereditary potentials by life experiences. In keeping with this idea, accumulating data suggest that epigenetic processes are implicated in eating-disorder (ED) etiology. This paper reviews literature on putative links between epigenetic factors and EDs, and examines ways in which epigenetic programming of gene expression could account for gene-environment interactions acting in the EDs. The paper also presents evidence suggesting that epigenetic processes link malnutrition and life stresses (gestational, perinatal, childhood, and adult) to risk of ED development. Drawing from empirical evidence and clinical experience, we propose that an epigenetically informed understanding of ED etiology can benefit patients, caregivers, and clinicians alike, in the sense that the perspective can reduce judgmental or blameful attitudes on the part of clinicians and caregivers, and increase self-acceptance and optimism about recovery on the part of those affected.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.