Evidence map›Paper›PMID 32375060›Full record

ArticleCell metabolism2020

From the Transcriptome to Electrophysiology: Searching for the Underlying Cause of Diabetes.

Vira Kravets, Richard K P Benninger

Open access · bronzeAbstract readComment
PubMed Publisher
In one paragraph

Article in Cell metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Vira KravetsDepartment of Bioengineering, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Barbara Davis Center of Childhood Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Richard K P BenningerDepartment of Bioengineering, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Barbara Davis Center of Childhood Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. Electronic address: richard.benninger@cuanschutz.edu.
University of Colorado Anschutz Medical Campus · US

Funding

Emergent Multi-Cellular Properties Regulating Pancreatic Islet FunctionR01DK106412 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Richard KP Benninger · 2015 to 2026
$4.0M
Multicellular Interactions and Dynamics of Pancreatic Islet Function in DiabetesR01DK102950 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI BENNINGER, RICHARD KP · 2015 to 2024
$3.5M
Emergent Multi-Cellular Properties Regulating Pancreatic Islet FunctionR56DK106412 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI BENNINGER, RICHARD KP · 2020 to 2020
$343k
NIDDK NIH HHS R01 DK106412NIDDK NIH HHS R56 DK106412
6 · The paper itself

Abstract

Cells within the islet of Langerhans are heterogeneous. Camunas-Soler et al. (2020) implement a patch-seq technique to collect both transcriptomic and electrophysiological data from the same cell. By doing so, they discover new genes that correlate with functional heterogeneity and find that shifts in these correlations indicate β cell compensation in type 2 diabetes.

Indexed as

Diabetes Mellitus, Type 2Insulin-Secreting CellsElectrophysiological PhenomenaElectrophysiologyHumansTranscriptome

Identifiers

PMID32375060
OpenAlexW3022256180

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.