ArticleCell reports2020
Antagonistic Center-Surround Mechanisms for Direction Selectivity in the Retina.
Article in Cell reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Rod photoreceptors control the ON vs OFF polarity of cone-signaling neurons.Communications biology · 2026Article
- Retinal ganglion cells encode the direction of motion outside their classical receptive field.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Top-down modulation of the retinal code via histaminergic neurons of the hypothalamus.Science advances · 2024Article
- Heterogeneous presynaptic receptive fields contribute to directional tuning in starburst amacrine cells.eLife · 2023Article
- Heterogeneous presynaptic receptive fields contribute to directional tuning in starburst amacrine cells.bioRxiv : the preprint server for biology · 2023Article
- Article
- Center-surround interactions underlie bipolar cell motion sensitivity in the mouse retina.Nature communications · 2022Article
- Sustained deep-tissue voltage recording using a fast indicator evolved for two-photon microscopy.Cell · 2022Article
- ON and OFF Signaling Pathways in the Retina and the Visual System.Frontiers in ophthalmology · 2022Article
- On the interplay of temporal resolution power and spatial suppression in their prediction of psychometric intelligence.PloS one · 2022Article
- Phase-Sensitive Measurements of Depth-Dependent Signal Transduction in the Inner Plexiform Layer.Frontiers in medicine · 2022Article
- Realistic retinal modeling unravels the differential role of excitation and inhibition to starburst amacrine cells in direction selectivity.PLoS computational biology · 2021Article
- Neuromorphic Analog Implementation of Neural Engineering Framework-Inspired Spiking Neuron for High-Dimensional Representation.Frontiers in neuroscience · 2021Article
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Authors and funding
5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
An antagonistic center-surround receptive field is a key feature in sensory processing, but how it contributes to specific computations such as direction selectivity is often unknown. Retinal On-starburst amacrine cells (SACs), which mediate direction selectivity in direction-selective ganglion cells (DSGCs), exhibit antagonistic receptive field organization: depolarizing to light increments and decrements in their center and surround, respectively. We find that a repetitive stimulation exhausts SAC center and enhances its surround and use it to study how center-surround responses contribute to direction selectivity. Center, but not surround, activation induces direction-selective responses in SACs. Nevertheless, both SAC center and surround elicited direction-selective responses in DSGCs, but to opposite directions. Physiological and modeling data suggest that the opposing direction selectivity can result from inverted temporal balance between excitation and inhibition in DSGCs, implying that SAC's response timing dictates direction selectivity. Our findings reveal antagonistic center-surround mechanisms for direction selectivity and demonstrate how context-dependent receptive field reorganization enables flexible computations.
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