ArticleCell reports2020
Replay of Learned Neural Firing Sequences during Rest in Human Motor Cortex.
Article in Cell reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00912041 (BrainGate2), which is not on this map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Tetraplegia
Who cites it
30 citing papers in PubMed, 76 citations in OpenAlex.
- Experience reorganizes content-specific memory traces in macaques.Nature neuroscience · 2026Article
- Review
- Controlling Spatio-Temporal Sequences of Neural Activity by Local Synaptic Changes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Article
- Article
- Electroacupuncture improves neurocognitive impairment induced by chronic sleep deprivation: an experimental study based on hippocampal neurogenesis and synaptic plasticity.Frontiers in human neuroscience · 2026Article
- Competition and cooperation of assembly sequences in recurrent neural networks.PLoS computational biology · 2025Article
- A novel robot-assisted method for implanting intracortical sensorimotor devices for brain-computer interface studies: principles, surgical techniques, and challenges.Journal of neurosurgery · 2025Article
- Article
- Tuned Compositional Feature Replays for Efficient Stream Learning.IEEE transactions on neural networks and learning systems · 2025Article
- Article
- Article
- Reactivation strength during cued recall is modulated by graph distance within cognitive maps.eLife · 2024Article
- Rest to Promote Learning: A Brain Default Mode Network Perspective.Behavioral sciences (Basel, Switzerland) · 2024Review
- High mirror symmetry in mouse exploratory behavior.Frontiers in behavioral neuroscience · 2024Article
- Locating causal hubs of memory consolidation in spontaneous brain network in male mice.Nature communications · 2023Article
- How our understanding of memory replay evolves.Journal of neurophysiology · 2023Review
- 3T vs. 7T fMRI: capturing early human memory consolidation after motor task utilizing the observed higher functional specificity of 7T.Frontiers in neuroscience · 2023Article
- Cognitive neuroscience perspective on memory: overview and summary.Frontiers in human neuroscience · 2023Article
- Persistence of hippocampal and striatal multivoxel patterns during awake rest after motor sequence learning.iScience · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 6 institutions in 1 country.
Funding
Abstract
The offline "replay" of neural firing patterns underlying waking experience, previously observed in non-human animals, is thought to be a mechanism for memory consolidation. Here, we test for replay in the human brain by recording spiking activity from the motor cortex of two participants who had intracortical microelectrode arrays placed chronically as part of a brain-computer interface pilot clinical trial. Participants took a nap before and after playing a neurally controlled sequence-copying game that consists of many repetitions of one "repeated" sequence sparsely interleaved with varying "control" sequences. Both participants performed repeated sequences more accurately than control sequences, consistent with learning. We compare the firing rate patterns that caused the cursor movements when performing each sequence to firing rate patterns throughout both rest periods. Correlations with repeated sequences increase more from pre- to post-task rest than do correlations with control sequences, providing direct evidence of learning-related replay in the human brain.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.