ArticleThe journals of gerontology. Series B, Psychological sciences and social sciences2020
Apathy and the Risk of Predementia Syndromes in Community-Dwelling Older Adults.
Article in The journals of gerontology. Series B, Psychological sciences and social sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Apathy as a Risky Neuropsychiatric Syndrome of Progression From Normal Aging to Mild Cognitive Impairment and Dementia: A Systematic Review and Meta-Analysis.Frontiers in psychiatry · 2021Pooled it
- Development and validation of screening tools for motoric cognitive risk syndrome in community settings.World journal of psychiatry · 2025Trial
- Trial
- Associations of Apathy and Depressive Symptoms With Frailty Domains in Individuals Aged 75 Years Old: A Cross-Sectional Study.Geriatrics & gerontology international · 2026Article
- Apathy Is Associated with Slower Gait and Subjective Cognitive Complaints in a South Indian Community-Dwelling Cohort.Brain sciences · 2025Article
- Diminished Social and Leisure Engagement in Community Dwelling-Older Adults with Apathy.International journal of environmental research and public health · 2025Article
- Virtual Life Story Club Intervention to Improve Loneliness and Apathy in Community-Dwelling Older Adults: Protocol for a Mixed Methods Feasibility Study.JMIR research protocols · 2025Article
- Associations between neuropsychiatric symptoms and motoric cognitive risk syndrome.BMC psychiatry · 2025Article
- Psychological predictors of incident subjective cognitive complaints in community dwelling older adults.Annals of medicine · 2024Article
- Stratifying Risk for Cognitive Decline in Older Adult Populations using the Geriatric Depression Scale.Journal of psychiatry and cognitive behaviour · 2024Article
- Caudate volume and symptoms of apathy in older adults with multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2023Article
- Epidemiology of Motoric Cognitive Risk Syndrome in the Kerala Einstein Study: Protocol for a Prospective Cohort Study.JMIR research protocols · 2023Article
- Motoric cognitive risk syndrome trajectories and incident dementia over 10 years.Cerebral circulation - cognition and behavior · 2023Article
- Prodromal Motoric Cognitive Risk Syndrome and Everyday Function.Journal of Alzheimer's disease : JAD · 2023Article
- Winning the race with aging: age-related changes in gait speed and its association with cognitive performance in dogs.Frontiers in veterinary science · 2023Article
- Mediation Analyses of the Role of Apathy on Motoric Cognitive Outcomes.International journal of environmental research and public health · 2022Article
- Reward System Dysfunction and the Motoric-Cognitive Risk Syndrome in Older Persons.Biomedicines · 2022Article
- Sarcopenia and motoric cognitive risk syndrome: a moderated mediation model.BMC geriatrics · 2022Article
- Brain-based mechanisms of late-life depression: Implications for novel interventions.Seminars in cell & developmental biology · 2021Review
- Apathy as a determinant of health behaviors in older adults: Implications for dementia risk reduction.Alzheimer's & dementia (Amsterdam, Netherlands)Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
objectivesApathy is a potential predictor of dementia in older adults, but this investigation has been limited to older adults with a preexisting neurological illness like mild cognitive impairment (MCI), stroke or Parkinson's disease. The objective of this study was to investigate the association between apathy at baseline and incident predementia syndromes, including MCI and motoric cognitive risk syndrome (MCR), subjective cognitive complaints and slow gait, in community-dwelling older adults.
methodWe prospectively studied the association between apathy (using the 3-item subscale of the Geriatric Depression Scale [GDS3A]) and incident cognitive disorders in 542 community-dwelling older adults enrolled in the Central Control of Mobility in Aging study using Cox proportional hazard models. Associations were reported as hazard ratio (HR) with 95% confidence intervals (CIs), adjusting for age, education, baseline cognitive performance, and depressive symptoms.
resultsApathy was associated with incident MCR (HR 2.39, 95% CI: 1.10-5.20), but not predementia syndromes overall nor MCI. In sensitivity analyses of MCI subtypes, apathy was associated with nonamnestic MCI (HR 2.44, 95% CI: 1.14-5.22), but not amnestic MCI. Our study was limited by a short follow-up time (median 13.6 months; interquartile range 29.8) and a brief subscale measurement of apathy, GDS3A. DISCUSSION: In our study, apathy predicted MCR but not MCI in community-dwelling older adults. These results and the current literature suggest that apathy is an early risk factor for dementia. Additionally, apathy may be a novel treatment target that could forestall the disability of dementia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.