Evidence map›Paper›PMID 32374619›Full record

ArticleAmerican journal of respiratory cell and molecular biology2020

Impaired Autophagic Activity Contributes to the Pathogenesis of Bronchopulmonary Dysplasia. Evidence from Murine and Baboon Models.

Liang Zhang, Sourabh Soni, Elvin Hekimoglu, Sara Berkelhamer, Sule Çataltepe

Open access · greenAbstract read
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.9field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Review
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  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Emerging role of cellular senescence in normal lung development and perinatal lung injury.Chinese medical journal pulmonary and critical care medicine · 2024
    Article
  13. Article
  14. AMPK Activation: Respiratory Panacea?American journal of respiratory cell and molecular biology · 2023
    Article
  15. Article
  16. Molecular mechanisms of cell death in bronchopulmonary dysplasia.Apoptosis : an international journal on programmed cell death · 2023
    Review
  17. Article
  18. Update in Pediatrics 2020.American journal of respiratory and critical care medicine · 2021
    Article
  19. Article
  20. Update in Critical Care 2020.American journal of respiratory and critical care medicine · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Liang ZhangDepartment of Pediatric Newborn Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Sourabh SoniDepartment of Pediatric Newborn Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Elvin HekimogluDepartment of Pediatric Newborn Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Sara BerkelhamerDivision of Newborn Medicine, State University of New York at Buffalo, Buffalo, New York.
Sule ÇataltepeDepartment of Pediatric Newborn Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Brigham and Women's Hospital · USUniversity at Buffalo, State University of New York · US

Funding

WNV REPLIVAX VACCINE IN NON-HUMAN PRIMATESP51RR013986 · NCRR · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI GOLDBERG, ERWIN · 1999 to 2011
$79.1M
Analysis of Airway Serpins in Baboon Models of BPDU01HL075904 · NHLBI · CHILDREN'S HOSPITAL BOSTON · PI CATALTEPE, SULE · 2003 to 2005
$748k
Autophagic Flux and Lysosomal Cathepsins in Neonatal Hyperoxia-induced Lung InjuryR21HD092934 · NICHD · BRIGHAM AND WOMEN'S HOSPITAL · PI CATALTEPE, SULE · 2017 to 2018
$462k
NCRR NIH HHS P51 RR013986NHLBI NIH HHS U01 HL075904NICHD NIH HHS R21 HD092934
6 · The paper itself

Abstract

Bronchopulmonary dysplasia (BPD) is a common and serious complication associated with preterm birth. The pathogenesis of BPD is incompletely understood, and there is an unmet clinical need for effective treatments. The role of autophagy as a potential cytoprotective mechanism in BPD remains to be fully elucidated. In the present study, we investigated the role and regulation of autophagy in experimental models of BPD. Regulation and cellular distribution of autophagic activity during postnatal lung development and in neonatal hyperoxia-induced lung injury (nHILI) were assessed in the autophagy reporter transgenic

Indexed as

Alveolar Epithelial CellsAnimalsAutophagyBeclin-1Bronchopulmonary DysplasiaDisease Models, AnimalHumansHyperoxiaLungLung InjuryMacrophages, AlveolarMice, KnockoutPneumoniaBeclin-1autophagybeclinbronchopulmonary dysplasiaGFP-LC3macrophage

Identifiers

PMID32374619
PMCPMC7462342
OpenAlexW3022812962

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.