ArticleBritish journal of clinical pharmacology2020
Pregabalin poisoning and rising recreational use: a retrospective observational series.
Article in British journal of clinical pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Pooled it
- Systematic review: The relationship between gabapentinoids, etizolam, and drug related deaths in Scotland.PloS one · 2024Pooled it
- Pregabalin-associated adverse drug reactions: A real-world pharmacovigilance study using WHO-VigiAccess.Medicine · 2026Article
- Probable pregabalin and amantadine-containing cold medication intoxication in an adolescent with rhabdomyolysis: Case report.Journal of Taibah University Medical Sciences · 2026Article
- Severe Illness Associated with Eating Mushroom-Containing Chocolate Products - United States, January-October 2024.MMWR. Morbidity and mortality weekly report · 2026Article
- Addressing the unanswered questions: a qualitative exploration focusing on community dwellers using pregabalin without prescription in Islamabad city, Pakistan.Substance abuse treatment, prevention, and policy · 2026Article
- Association between gabapentinoid treatment, concurrent use with opioid or benzodiazepine and the risk of drug poisoning: A self-controlled case series study.PLoS medicine · 2026Article
- Effect of Pregabalin on the Development ofInsects · 2026Article
- Monitoring pregabalin use through online interest: A trend analysis using google search and consumption data.Indian journal of psychiatry · 2025Article
- Seizures as an Adverse Effect of Pregabalin Consumption: A Systematic Review.Addiction & health · 2025Review
- Characteristics of Non-Therapeutic Pregabalin Users Detected by a Community Pharmacies Network in a Region of Southern Europe.Journal of clinical medicine · 2024Article
- Case report: A comatose patient with pregabalin overdose successfully treated with continuous renal replacement therapy.Frontiers in medicine · 2023Article
- Rise of Pregabalin Poisoning and Abuse Cases in Serbia: A Ten-Year Retrospective Study.International journal of general medicine · 2023Article
- Who prescribes quetiapine in Denmark?British journal of clinical pharmacology · 2022Article
- Article
- Pregabalin poisoning: Evaluation of dose-toxicity relationship.British journal of clinical pharmacology · 2022Article
- Pregabalin prescribing patterns in Australian general practice, 2012-2018: a cross-sectional study.BJGP open · 2021Article
- Pregabalin poisoning and rising recreational use: a retrospective observational series.British journal of clinical pharmacology · 2020Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
aimsWith rising use worldwide, pregabalin is increasingly implicated in poisoning deaths. We aimed to investigate the clinical effects and complications of pregabalin poisoning.
methodsThis is a retrospective review of patients presenting with pregabalin poisoning to two tertiary toxicology units from 1 July 2014 to 30 June 2019. Patients were identified from prospective databases maintained by both units and data were extracted from these in addition to medical records.
resultsThere were 488 presentations in 413 patients (237 [57%] male) over the five-year period. The median age was 41 years (IQR 31-50 years). Deliberate self-poisonings accounted for 342 (70%) presentations, with 121 (25%) recreational exposures. Recreational exposures increased over the period from 2 (4%) in the first year to 54 (39%) presentations in the final year. The median dose of pregabalin was 1200 mg (IQR 600-3000 mg, range 75-16 800 mg). Co-ingestions occurred in 427 (88%) presentations, with sedating agents being co-ingested in 387 (79%)-most commonly opioids and benzodiazepines in 201 (41%) and 174 (36%) presentations respectively. Coma (GCS < 9) occurred in 89 (18%) cases, with 52 (11%) patients being intubated. Only one (0.2%) of these patients had not co-ingested a sedating agent. Hypotension occurred in 26 (5%) cases, all with co-ingestants. Seizures occurred in 11 (2%) cases, 3/59 (5%) in pregabalin-only overdoses. The median length of stay was 16.5 hours (IQR 10-25 hours).
conclusionsPregabalin overdose does not cause severe toxicity, but rather mild sedation and, uncommonly, seizures. Coma is common in the presence of sedating co-ingestants. Recreational use is increasing.
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