Evidence map›Paper›PMID 32374202›Full record

ArticleJournal of neurophysiology2020

LRRK2 mutation alters behavioral, synaptic, and nonsynaptic adaptations to acute social stress.

Christopher A Guevara, Bridget A Matikainen-Ankney, Nebojsa Kezunovic, Katherine LeClair, Alexander P Conway, Caroline Menard, Meghan E Flanigan, Madeline Pfau, Scott J Russo, Deanna L Benson and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of neurophysiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
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  4. Affective phenotypes in heterozygousFrontiers in genetics · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Christopher A GuevaraNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York.ORCID 0000-0001-6755-9317
Bridget A Matikainen-AnkneyNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York.ORCID 0000-0001-9217-2448
Nebojsa KezunovicNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York.ORCID 0000-0001-8623-2002
Katherine LeClairNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York.ORCID 0000-0003-2075-7740
Alexander P ConwayNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York.
Caroline MenardNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York.ORCID 0000-0001-8202-7378
Meghan E FlaniganNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York.ORCID 0000-0002-3185-7459
Madeline PfauNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York.
Scott J RussoNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York.ORCID 0000-0002-6470-1805
Deanna L BensonNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York.ORCID 0000-0001-7037-1147
George W HuntleyNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York.ORCID 0000-0003-3645-6192
Allen Institute for Brain Science · USIcahn School of Medicine at Mount Sinai · US

Funding

Training Program in NeuroscienceT32MH087004 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GEORGE W. HUNTLEY · 2009 to 2026
$4.0M
Impact of human disease-causing mutation on striatal synaptic and behavioral plasticityR01NS107512 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BENSON, DEANNA L, HUNTLEY, GEORGE W. · 2019 to 2022
$2.1M
Cdh8-dependent circuit development in autismR01MH104491 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BENSON, DEANNA L, HUNTLEY, GEORGE W. · 2016 to 2020
$1.9M
Susceptibility to depression by human disease-causing mutationR21MH110727 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HUNTLEY, GEORGE W. · 2017 to 2018
$466k
NIH-NIMH R01MH104491NIH-NIMH R21MH110727NIH-NIMH T32MH087004NIH-NINDS R01NS107512NIMH NIH HHS R01 MH104491NIMH NIH HHS R21 MH110727NIMH NIH HHS T32 MH087004NINDS NIH HHS R01 NS107512
6 · The paper itself

Abstract

Parkinson's disease (PD) risk is increased by stress and certain gene mutations, including the most prevalent PD-linked mutation

Indexed as

Behavior, AnimalDepressionElectrophysiological PhenomenaExcitatory Postsynaptic PotentialsNucleus AccumbensParkinson DiseaseStress, PsychologicalAnimalsDisease Models, AnimalFemaleLeucine-Rich Repeat Serine-Threonine Protein Kinase-2MaleMiceMice, Inbred C57BLMice, TransgenicLeucine-Rich Repeat Serine-Threonine Protein Kinase-2Lrrk2 protein, mouseEPSCsG2019Sintrinsic excitabilitynucleus accumbensParkinson’s diseasesocial defeat stress

Identifiers

PMID32374202
PMCPMC7311730
OpenAlexW3020923383

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.