ArticleAmerican journal of respiratory and critical care medicine2020
Increased Alternative Complement Pathway Function and Improved Survival during Critical Illness.
Open access · hybridAbstract read
In one paragraph
Article in American journal of respiratory and critical care medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 47 citations in OpenAlex.
- Article
- Connections betweenInfection and immunity · 2026Article
- Disentangling Links Between Lung Cancer and Infectious Pneumonia via Real-World Data and Integrative Genomics.Human mutation · 2026Article
- Genetic Variation in the Alternative Complement Pathway Contributes to Individual Susceptibility to Bacteremia and Sepsis.Critical care explorations · 2025Article
- Divergent roles for complement components C3 and C4 in controllingbioRxiv : the preprint server for biology · 2025Article
- Rapid and Integrated Bacterial Evolution Analysis unveils gene mutations and clinical risk of Klebsiella pneumoniae.Nature communications · 2025Article
- Review
- Clinical and biologic profiles of patients with acute respiratory distress syndrome by prevalence of chronic obstructive pulmonary disease or emphysema; a cohort study.Respiratory research · 2024Article
- Complement system activation: bridging physiology, pathophysiology, and therapy.Intensive care medicine · 2024Review
- Local complement activation and modulation in mucosal immunity.Mucosal immunology · 2024Review
- In Vivo Evolution of a Klebsiella pneumoniae Capsule Defect With wcaJ Mutation Promotes Complement-Mediated Opsonophagocytosis During Recurrent Infection.The Journal of infectious diseases · 2024Article
- Clinical features and multiomics profiles indicate coagulation and platelet dysfunction in COVID-19 viral sepsis.iScience · 2024Article
- Lung Epithelium Releases Growth Differentiation Factor 15 in Response to Pathogen-mediated Injury.American journal of respiratory cell and molecular biology · 2024Article
- "Now We Got Bad Blood": Beyond Phenotype Labels in an "Era" of Meta-omics in Critical Illness.American journal of respiratory and critical care medicine · 2024Article
- Characteristics of Immunocytes and Cytokines in Patients with Bloodstream Infections Caused by Carbapenem-ResistantInfection and drug resistance · 2024Article
- Factor H preserves alternative complement function during ARDS, linked to improved survival.ERJ open research · 2023Article
- Lung epithelial cell-derived C3 protects against pneumonia-induced lung injury.Science immunology · 2023Article
- The ultimate tradeoff: how red cell adaptations to malaria alter the host response during critical illness.American journal of physiology. Lung cellular and molecular physiology · 2023Review
- Low-molecular weight inhibitors of the alternative complement pathway.Immunological reviews · 2023Review
- Contribution of Coronavirus-Specific Immunoglobulin G Responses to Complement Overactivation in Patients with Severe Coronavirus Disease 2019.The Journal of infectious diseases · 2022Article
Corrections and comments
- Commented on by
Authors and funding
25 authors at 8 institutions in 1 country.
William BainAcute Lung Injury Center of Excellence, Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine.
Huihua LiDepartment of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin.
Rick van der GeestAcute Lung Injury Center of Excellence, Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine.
Sara R MooreDepartment of Medical Microbiology and Immunology, University of Toledo College of Life Sciences, Toledo, Ohio.
Tolani F OlonisakinAcute Lung Injury Center of Excellence, Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine.
Brian AhnAcute Lung Injury Center of Excellence, Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine.
Erin PapkeAcute Lung Injury Center of Excellence, Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine.
Kaveh MoghbeliAcute Lung Injury Center of Excellence, Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine.
Rebecca DeSensiAcute Lung Injury Center of Excellence, Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine.
Sarah RapportAcute Lung Injury Center of Excellence, Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine.
Melissa SaulAcute Lung Injury Center of Excellence, Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine.
Mei HulverAcute Lung Injury Center of Excellence, Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine.
Zeyu XiongAcute Lung Injury Center of Excellence, Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine.
Rama K MallampalliDepartment of Medicine, Ohio State University, Columbus, Ohio; and.
Prabir RayAcute Lung Injury Center of Excellence, Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine.
Alison MorrisAcute Lung Injury Center of Excellence, Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine.
Lina MaDivision of Pulmonary and Critical Care Medicine, Washington University, St. Louis, Missouri.
Yohei DoiDivision of Infectious Diseases, Department of Medicine, and.
Yingze ZhangAcute Lung Injury Center of Excellence, Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine.
Georgios D KitsiosAcute Lung Injury Center of Excellence, Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine.
Hrishikesh S KulkarniDivision of Pulmonary and Critical Care Medicine, Washington University, St. Louis, Missouri.
Bryan J McVerryAcute Lung Injury Center of Excellence, Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine.
Viviana P FerreiraDepartment of Medical Microbiology and Immunology, University of Toledo College of Life Sciences, Toledo, Ohio.
Mehdi NouraieAcute Lung Injury Center of Excellence, Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine.
Janet S LeeAcute Lung Injury Center of Excellence, Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine.
Advanced ENT and Allergy · USUniversity of Pittsburgh · USUniversity of Toledo Medical Center · USWashington University in St. Louis · USOffice of Infectious Diseases · USThe Ohio State University · USUniversity of Wisconsin–Madison · USVeterans Health Administration · US
Funding
Regulation of Cardiolin Byosynthesis in Epithelial InjuryP01HL114453 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KAGAN, VALERIAN E · 2014 to 2023
$21.3MTranslational Training Program in Pulmonary Biology and MedicineT32HL007563 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Melanie Koenigshoff · 1985 to 2026
$12.3MF box-Induced Acute Lung Injury and ParkinR01HL096376 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MALLAMPALLI, RAMA K · 2010 to 2025
$5.1MSepsis-Associated Immune Suppression and F-box ProteinsR01HL097376 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MALLAMPALLI, RAMA K · 2009 to 2025
$5.1MMechanisms of host protection against pathogen-secreted proteases in acute lung injuryR01HL136143 · NHLBI · WASHINGTON UNIVERSITY · PI LEE, JANET SOJUNG · 2017 to 2024
$4.4MThe role of ACOD1 in immunomodulation in intrapulmonary Klebsiella pneumoniae infectionR01HL142084 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHEN, KONG · 2018 to 2021
$2.4MRole of complement regulator properdin in the interaction between platelets and lR01HL112937 · NHLBI · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI FERREIRA, VIVIANA P · 2014 to 2018
$1.9MC3 Mitigates Epithelial Injury in PneumoniaK08HL148510 · NHLBI · WASHINGTON UNIVERSITY · PI KULKARNI, HRISHIKESH SATISH · 2019 to 2023
$740kPatient-Oriented Research in Acute Lung Injury and Host Defense in the ICUK24HL143285 · NHLBI · WASHINGTON UNIVERSITY · PI LEE, JANET SOJUNG · 2019 to 2023
$579kMentoring and Patient-Oriented Research in HIV Obstructive Lung DiseaseK24HL123342 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MORRIS, ALISON · 2014 to 2018
$571kMechanisms of platelet protection in pathogen-triggered lung injuryF32HL142172 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BAIN, WILLIAM G · 2018 to 2019
$103kPlatelet factors attenuate alveolar injury during severe pneumoniaIK2BX004886 · VA · VETERANS HEALTH ADMINISTRATION · PI BAIN, WILLIAM G · 2020 to 2024
–BLRD VA IK2 BX004886NHLBI NIH HHS F32 HL142172NHLBI NIH HHS K08 HL148510NHLBI NIH HHS K24 HL123342NHLBI NIH HHS K24 HL143285NHLBI NIH HHS L30 HL143734NHLBI NIH HHS P01 HL114453NHLBI NIH HHS R01 HL096376NHLBI NIH HHS R01 HL097376NHLBI NIH HHS R01 HL112937NHLBI NIH HHS R01 HL136143NHLBI NIH HHS R01 HL142084NHLBI NIH HHS T32 HL007563
Abstract
PubMed holds no abstract for this paper.
Indexed as
Survival AnalysisAgedAnimalsComplement Pathway, AlternativeCritical IllnessFemaleHumansMaleMiceMiddle AgedPennsylvaniaPneumoniaRetrospective Studiescomplementcritical illnesshost defensepneumoniaserum
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.