Evidence map›Paper›PMID 32374053›Full record

SynthesisThe oncologist2020

Whole-Body Characterization of Estrogen Receptor Status in Metastatic Breast Cancer with 16α-18F-Fluoro-17β-Estradiol Positron Emission Tomography: Meta-Analysis and Recommendations for Integration into Clinical Applications.

Brenda F Kurland, Jay R Wiggins, Amandine Coche, Charlotte Fontan, Yann Bouvet, Peter Webner, Chaitanya Divgi, Hannah M Linden

Open access · greenAbstract readMeta-AnalysisReview
In one paragraph

Synthesis in The oncologist, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 2 pooled it
4.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 2 syntheses or guidelines pooled it, 96 citations in OpenAlex.

  1. The Role of Estrogen Receptor-Targeted PET with 16α-Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Pooled it
  2. Pooled it
  3. Trial
  4. Utilization ofAdvances in radiation oncology · 2026
    Article
  5. DiscordantEuropean journal of nuclear medicine and molecular imaging · 2026
    Article
  6. Article
  7. Real-world application ofEuropean journal of nuclear medicine and molecular imaging · 2026
    Article
  8. European journal of nuclear medicine and molecular imaging · 2025
    Article
  9. Article
  10. The Role of [Cancers · 2025
    Review
  11. Preclinical evaluation ofBreast cancer research : BCR · 2025
    Article
  12. [EJNMMI research · 2025
    Article
  13. Review
  14. Article
  15. Review
  16. Review
  17. Dynamic whole-body [EJNMMI research · 2024
    Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Brenda F KurlandUniversity of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID https://orcid.org/0000-0002-5669-0595
Jay R WigginsMerlin Biomedical Consulting, LLC, Hendersonville, North Carolina, USA.
Amandine CocheZionexa US Corporation, Fishers, Indiana, USA.
Charlotte FontanZionexa US Corporation, Fishers, Indiana, USA.
Yann BouvetZionexa US Corporation, Fishers, Indiana, USA.
Peter WebnerZionexa US Corporation, Fishers, Indiana, USA.
Chaitanya DivgiDivgi Consulting LLC, Meadowbrook, Pennsylvania, USA.
Hannah M LindenUniversity of Washington, Seattle, Washington, USA.
University of Pittsburgh · USUniversity of Washington · US

Funding

RadiochemistryP01CA042045 · NCI · UNIVERSITY OF WASHINGTON · PI EARY, JANET F. · 1986 to 2015
$23.2M
NCI NIH HHS CA42045NCI NIH HHS #N01-CM-37008NCI NIH HHS P01 CA042045Zionexa
6 · The paper itself

Abstract

Estrogen receptor (ER) status by immunohistochemistry (IHC) of cancer tissue is currently used to direct endocrine therapy in breast cancer. Positron emission tomography (PET) with 16α-18F-fluoro-17β-estradiol (

Indexed as

Breast NeoplasmsReceptors, EstrogenBiopsyEstradiolFemaleHumansPositron-Emission TomographyRadiopharmaceuticalsEstradiolRadiopharmaceuticalsReceptors, Estrogen16α-18F-fluoro-17β-estradiolEstrogen receptorImmunohistochemistryMeta-analysisMetastatic breast cancerPositron emission tomographyTissue biopsy

Identifiers

PMID32374053
PMCPMC7543360
OpenAlexW3022232398

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.