ArticleJNCI cancer spectrum2020
Determinants of Mammographic Breast Density by Race Among a Large Screening Population.
Article in JNCI cancer spectrum, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07782814 (An Investigation Into Dielectric Testing for the Evaluation and Characterisation of Breast Tissue Using a Novel Time-Domain Bioimpedance Tool), which is not on this map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
An Investigation Into Dielectric Testing for the Evaluation and Characterisation of Breast Tissue Using a Novel Time-Domain Bioimpedance Tool
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Chemoprevention Agents to Reduce Mammographic Breast Density in Premenopausal Women: A Systematic Review of Clinical Trials.JNCI cancer spectrum · 2021Pooled it
- Article
- Association between Participant Characteristics and Breast Parenchymal Texture Variation among Postmenopausal Women.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2026Article
- Where are we now and where do we go from here? A structured literature review analyzing the current state of breast density research trends and discussions.Cancer causes & control : CCC · 2025Review
- Interplay of BMI and volumetric breast density measures and breast cancer risk for black and white women.Breast cancer research : BCR · 2025Article
- Reproductive determinants of mammographic density in black women.Cancer causes & control : CCC · 2025Article
- Racial Differences in Screening Eligibility by Breast Density After State-Level Insurance Expansion.JAMA network open · 2025Article
- Deriving a Mammogram-Based Risk Score from Screening Digital Breast Tomosynthesis for 5-Year Breast Cancer Risk Prediction.Cancer prevention research (Philadelphia, Pa.) · 2025Article
- The Use of Breast Cup Immobilization in Radiation Therapy and Patient-Reported Outcomes on Cosmesis and Pain.Advances in radiation oncology · 2025Article
- Metabolites and lipid species mediate the associations of adiposity in childhood and early adulthood with mammographic breast density in premenopausal women.Breast cancer research : BCR · 2025Article
- Automated Breast Density Assessment for Full-Field Digital Mammography and Digital Breast Tomosynthesis.Cancer prevention research (Philadelphia, Pa.) · 2025Article
- Lifecourse Growth and Development Determinants of Mammographic Density in Black Women.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2024Article
- PFAS Levels, Early Life Factors, and Mammographic Breast Density in Premenopausal Women.Environmental health perspectives · 2024Article
- Association of breast cancer with quantitative mammographic density measures for women receiving contrast-enhanced mammography.JNCI cancer spectrum · 2024Article
- Can multi-modal radiomics using pretreatment ultrasound and tomosynthesis predict response to neoadjuvant systemic treatment in breast cancer?European radiology · 2024Article
- Reproductive risk factors for breast cancer and association with novel breast density measurements among Hispanic, Black, and White women.Breast cancer research and treatment · 2024Article
- Gynecologic Care of Black Breast Cancer Survivors.Current breast cancer reports · 2024Article
- Generalisable deep learning method for mammographic density prediction across imaging techniques and self-reported race.Communications medicine · 2024Article
- Associations of Vitamins and Related Cofactor Metabolites with Mammographic Breast Density in Premenopausal Women.The Journal of nutrition · 2024Article
- Machine learning for predicting neoadjuvant chemotherapy effectiveness using ultrasound radiomics features and routine clinical data of patients with breast cancer.Frontiers in oncology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundBecause of the mixed reports from smaller studies, we examined associations of race with mammographic breast density and evaluated racial differences in the determinants of breast density.
methodsParticipants included 37 839 women (23 166 non-Hispanic white and 14 673 African American) receiving screening mammograms at the Joanne Knight Breast Health Center at Washington University School of Medicine from June 2010 to December 2015. Mammographic breast density was assessed using the Breast Imaging Reporting and Data System (5th edition). To determine the association of race and participant characteristics with mammographic breast density, we used multivariable polytomous logistic regression models (reference group: almost entirely fatty).
resultsAfrican American women had increased odds of extremely dense (adjusted odds ratio = 1.31, 95% confidence interval = 1.13 to 1.52) and reduced odds of heterogeneously dense breasts (adjusted odds ratio = 0.91, 95% confidence interval = 0.84 to 0.99) compared with non-Hispanic white women. Altogether, race, parity and age at first birth, current age, current body mass index (BMI), BMI at age 18 years, menarche, family history of breast cancer, oral contraceptive use, alcohol use, and menopausal status explained 33% of the variation in mammographic breast density. Among African American and non-Hispanic white women, these factors explained nearly 28.6% and 33.6% of the variation in mammographic density, respectively. Current BMI provided the greatest explanation of breast density (26.2% overall, 22.2% in African American, and 26.2% in non-Hispanic white women).
conclusionsThe determinants of mammographic breast density were generally similar between African American women and non-Hispanic white women. After adjustments for confounders, African Americans had higher likelihood of extremely dense breasts but lower likelihood of heterogeneously dense breasts. The greatest explanation of breast density was provided by BMI, regardless of race.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.