Evidence map›Paper›PMID 32373678›Full record

ArticleBone reports2020

Transient receptor potential vanilloid 1 and 4 double knockout leads to increased bone mass in mice.

Haruki Nishimura, Makoto Kawasaki, Manabu Tsukamoto, Kunitaka Menuki, Hitoshi Suzuki, Takanori Matsuura, Kazuhiko Baba, Yasuhito Motojima, Teruaki Fujitani, Hideo Ohnishi and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bone reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Mechanosignaling in Osteoporosis: When Cells Feel the Force.International journal of molecular sciences · 2025
    Review
  3. Roles of TRPM channels in glioma.Cancer biology & therapy · 2024
    Review
  4. Article
  5. Review
  6. Water Extract ofNutrients · 2022
    Article
  7. Review
  8. Article
  9. The role of TRPV channels in osteoporosis.Molecular biology reports · 2022
    Review
  10. Role of KInternational journal of molecular sciences · 2021
    Review
  11. New Advances in Osteocyte Mechanotransduction.Current osteoporosis reports · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 2 institutions in 1 country.

Haruki NishimuraDepartment of Orthopaedic Surgery, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan.
Makoto KawasakiDepartment of Orthopaedic Surgery, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan.
Manabu TsukamotoDepartment of Orthopaedic Surgery, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan.
Kunitaka MenukiDepartment of Orthopaedic Surgery, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan.
Hitoshi SuzukiDepartment of Orthopaedic Surgery, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan.
Takanori MatsuuraDepartment of Orthopaedic Surgery, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan.
Kazuhiko BabaDepartment of Orthopaedic Surgery, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan.
Yasuhito MotojimaDepartment of Orthopaedic Surgery, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan.
Teruaki FujitaniDepartment of Orthopaedic Surgery, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan.
Hideo OhnishiDepartment of Orthopaedic Surgery, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan.
Yoshiaki YamanakaDepartment of Orthopaedic Surgery, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan.
Kenji KosugiDepartment of Orthopaedic Surgery, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan.
Yasuaki OkadaDepartment of Orthopaedic Surgery, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan.
Kotaro TokudaDepartment of Orthopaedic Surgery, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan.
Takafumi TajimaDepartment of Orthopaedic Surgery, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan.
Toru YoshiokaDepartment of Orthopaedics, Shimura Hospital, 3-13 Funairimachi Naka-ku, Hiroshima 730-0841, Japan.
Nobukazu OkimotoOkimoto Clinic, 185-4 Yutakamachikubi, Kure, Hiroshima 734-0304, Japan.
Yoichi UetaDepartment of Physiology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan.
Akinori SakaiDepartment of Orthopaedic Surgery, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan.
University of Occupational and Environmental Health Japan · JPKawamura Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Calcium balance is important in bone homeostasis. The transient receptor potential vanilloid (TRPV) channel is a nonselective cation channel permeable to calcium and is activated by various physiological and pharmacological stimuli. TRPV1 and TRPV4, in particular, have important roles in intracellular Ca

Indexed as

ALP, alkaline phosphataseBMD, bone mineral densityBMSCs, bone marrow mesenchymal stem cellsBone histomorphometryCB, cannabinoidCell cultureCT, computed tomographyDKO, double knock outDXA, dual-energy X-ray absorptionMicro-CTMNCs, multinucleated cellsOsteogenesisPCR, polymerase chain reactionPOc, preosteoclastPreosteoclastRANKL, receptor activator of nuclear factor-kappa B ligandRANK, receptor activator of nuclear factor-kappa BTRACP, tartrate-resistant acid phosphataseTransient receptor potential vanilloidTRPV, transient receptor potential vanilloidV1KO, TRPV1 knock outV4KO, TRPV4 knock outWT, wild type

Identifiers

PMID32373678
PMCPMC7191598
OpenAlexW3017735460

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.