Evidence map›Paper›PMID 32373644›Full record

ArticleJournal of sports medicine (Hindawi Publishing Corporation)2020

Diagnosis of Overtraining Syndrome: Results of the Endocrine and Metabolic Responses on Overtraining Syndrome Study: EROS-DIAGNOSIS.

Flavio Adsuara Cadegiani, Pedro Henrique Luiz da Silva, Tatiana Camargo Pereira Abrao, Claudio Elias Kater

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of sports medicine (Hindawi Publishing Corporation), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06295016 (Influence of Stressors and Recovery Regulation on the Super-compensation Effect of Endurance Athletes After High-intensity Intensive Training), which is not on this map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06295016 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Influence of Stressors and Recovery Regulation on the Super-compensation Effect of Endurance Athletes After High-intensity Intensive Training

TypeinterventionalSponsorNational Yang Ming Chiao Tung UniversityRan2023 to 2025Enrolled158ConditionsExercise Overtraining, Stressor, PsychologicalArmsHigh-intensity intensive training, Taper
3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. The Athlete's Paradox: Adaptable Depression.Sports (Basel, Switzerland) · 2022
    Article
  8. Review
  9. Article
  10. Overtraining Syndrome as a Complex Systems Phenomenon.Frontiers in network physiology · 2021
    Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Flavio Adsuara CadegianiAdrenal and Hypertension Unit, Division of Endocrinology and Metabolism, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo (EPM/UNIFESP), São Paulo, SP, Brazil.ORCID https://orcid.org/0000-0002-2699-4344
Pedro Henrique Luiz da SilvaAdrenal and Hypertension Unit, Division of Endocrinology and Metabolism, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo (EPM/UNIFESP), São Paulo, SP, Brazil.
Tatiana Camargo Pereira AbraoAdrenal and Hypertension Unit, Division of Endocrinology and Metabolism, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo (EPM/UNIFESP), São Paulo, SP, Brazil.
Claudio Elias KaterAdrenal and Hypertension Unit, Division of Endocrinology and Metabolism, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo (EPM/UNIFESP), São Paulo, SP, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesOvertraining syndrome (OTS), a common dysfunction among elite athletes, causes decreased performance and fatigue and has no standardized diagnostic criteria. The Endocrine and Metabolic Responses on Overtraining Syndrome (EROS) study identified more than 45 potential biomarkers of OTS. In the present study, we hypothesized that combinations of these biomarkers could be an accurate diagnostic tool for OTS.

methodsWe selected parameters with largest difference and fewest overlapping results compared to healthy athletes and highest feasibility and reproducibility. Among the multiple combinations attempted, we chose those that did not show overlapping results, according to the objective.

resultsWe included 11 clinical parameters, 4 basal hormones, and 5 hormonal responses in Insulin Tolerance Test (ITT). The three selected diagnostic tools were the (i) EROS-CLINICAL, with only clinical parameters, which was suitable as an initial assessment for athletes suspected of OTS; (ii) EROS-SIMPLIFIED, with clinical parameters and basal hormones, when the EROS-CLINICAL was inconclusive; and (iii) EROS-COMPLETE, with basal and hormonal responses to stimulation tests, which was valuable for population-based screening, research purposes, and unusual presentations of OTS.

conclusionWe identified innovative tools with 100% accuracy for the diagnosis of OTS, without the need to exclude confounding disorders.

Identifiers

PMID32373644
PMCPMC7193300

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.