Evidence map›Paper›PMID 32373540›Full record

ArticleFrontiers in oncology2020

The Role of Palliative Surgery for Malignant Bowel Obstruction and Perforation in Advanced Microsatellite Instability-High Colorectal Carcinoma in the Era of Immunotherapy: Case Report.

Sean J Judge, Jingran Ji, James Liu, Manmeet Kaur, Edward Kim, Jun Gong, Kit W Tam, Amanda R Kirane, Sepideh Gholami, Robert J Canter and 4 more

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Sean J JudgeDivision of Surgical Oncology, Department of Surgery, University of California, Davis, Sacramento, CA, United States.
Jingran JiDepartment of Internal Medicine, University of California, Davis, Sacramento, CA, United States.
James LiuDivision of Hematology and Oncology, Department of Medicine, University of California, Davis, Sacramento, CA, United States.
Manmeet KaurDepartment of Internal Medicine, University of California, Davis, Sacramento, CA, United States.
Edward KimDivision of Hematology and Oncology, Department of Medicine, University of California, Davis, Sacramento, CA, United States.
Jun GongDivision of Hematology and Oncology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
Kit W TamDivision of Hematology and Oncology, Department of Medicine, University of California, Davis, Sacramento, CA, United States.
Amanda R KiraneDivision of Surgical Oncology, Department of Surgery, University of California, Davis, Sacramento, CA, United States.
Sepideh GholamiDivision of Surgical Oncology, Department of Surgery, University of California, Davis, Sacramento, CA, United States.
Robert J CanterDivision of Surgical Oncology, Department of Surgery, University of California, Davis, Sacramento, CA, United States.
Richard J BoldDivision of Surgical Oncology, Department of Surgery, University of California, Davis, Sacramento, CA, United States.
Alexandra GangiDivision of Surgical Oncology, Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
Marwan FakihDivision of Hematology and Oncology, Department of Medicine, City of Hope National Medical Center, Duarte, CA, United States.
May ChoDivision of Hematology and Oncology, Department of Medicine, University of California, Davis, Sacramento, CA, United States.
University of California, Davis · USCedars-Sinai Medical Center · USCity Of Hope National Medical Center · US

Funding

UC Davis Paul Calabresi K12 Clinical Oncology Research Career Development ProgramK12CA138464 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BIRKELAND, ANDREW CHARLES, LARA, PRIMO N. · 2011 to 2025
$11.4M
NCI NIH HHS K12 CA138464
6 · The paper itself

Abstract

The role of palliative surgery in the management of acute complications in patients with disseminated malignancy remains controversial given the complexity of assessing acute surgical risk and long-term oncologic outcome. With the emergence of checkpoint blockade immunotherapy, there appears to be an increasing role for historically palliative procedures as a bridge to systemic immunotherapy. This is especially evident in advanced microsatellite instability-high (MSI-H) colorectal cancer where malignant obstruction and fistula formation are more common and where immunotherapy with checkpoint blockade (anti-PD-1/PD-L1, anti-CTLA-4) has a high response rate with potential for favorable oncologic outcomes. We present a series of three patients with MSI-H metastatic colorectal cancer complicated by malignant bowel obstruction and fistula formation, who having progressed on standard chemotherapy, underwent palliative intervention as a bridge to immune checkpoint blockade with durable and clinically meaningful anti-cancer responses. These cases highlight the need to re-evaluate the role of historically palliative operations in the setting of disease progression for immunotherapy-responsive tumors.

Indexed as

immunotherapymalignant bowel obstructionmetastatic colorectal adenocarcinomamicrosatellite instability high (MSI-H)palliative surgery

Identifiers

PMID32373540
PMCPMC7186327
OpenAlexW3016438178

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.