ReviewDepression research and treatment2020
Epigenetic Mechanisms in the Neurodevelopmental Theory of Depression.
Review in Depression research and treatment, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association of hearing loss and risk of depression: a systematic review and meta-analysis.Frontiers in neurology · 2024Pooled it
- Cascading model of causal relationships in EMS ontogeny: integration of Piaget, Erikson, Bowlby, and Young paradigms.Frontiers in psychiatry · 2026Review
- Relationships between primal emotional systems and the sense of loneliness: The mediating role of early maladaptive schemas.PloS one · 2026Article
- Exploring the Link Between the Gut Microbiota and Epigenetic Factors in Anorexia Nervosa.Brain and behavior · 2025Review
- Delving Into the Interaction Between Exercise and Diabetes on Methylation of the FKBP5 Gene.Journal of diabetes research · 2025Article
- Epigenetic and Coping Mechanisms of Stress in Affective Disorders: A Scoping Review.Medicina (Kaunas, Lithuania) · 2024Article
- FKBP5, a Modulator of Stress Responses Involved in Malignant Mesothelioma: The Link between Stress and Cancer.International journal of molecular sciences · 2023Article
- Targeting the Arginine Vasopressin VNeuropsychiatric disease and treatment · 2023Review
- Maternal Distress during Pregnancy and the Postpartum Period: Underlying Mechanisms and Child's Developmental Outcomes-A Narrative Review.International journal of molecular sciences · 2022Review
- Human FKBP5 Negatively Regulates Transcription through Inhibition of P-TEFb Complex Formation.Molecular and cellular biology · 2022Article
- Nutrition, Epigenetics, and Major Depressive Disorder: Understanding the Connection.Frontiers in nutrition · 2022Review
- Environmental enrichment improves lifelong persistent behavioral and epigenetic changes induced by early-life stress.Journal of psychiatric research · 2021Article
- Vorinostat (SAHA) May Exert Its Antidepressant-Like Effects Through the Modulation of Oxidative Stress Pathways.Neurotoxicity research · 2021Article
- Creative, Person-Centered Narrative Psychopharmacotherapy of Depression.Advances in experimental medicine and biology · 2021Article
- The neuroendocrine modulation of global DNA methylation in neuropsychiatric disorders.Molecular psychiatry · 2021Review
- Beyond Haemostasis and Thrombosis: Platelets in Depression and Its Co-Morbidities.International journal of molecular sciences · 2020Review
- Effects of Early-Life Stress on the Brain and Behaviors: Implications of Early Maternal Separation in Rodents.International journal of molecular sciences · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The genome (genes), epigenome, and environment work together from the earliest stages of human life to produce a phenotype of human health or disease. Epigenetic modifications, including among other things: DNA methylation, modifications of histones and chromatin structure, as well as functions of noncoding RNA, are coresponsible for specific patterns of gene expression. This refers also to mental disorders, including depressive disorders. Early childhood experiences accompanied by severe stressors (considered a risk factor for depression in adult life) are linked with changes in gene expression. They include genes involved in a response to stress (hypothalamic-pituitary-adrenal axis, HPA), associated with autonomic nervous system hyperactivity and with cortical, and subcortical processes of neuroplasticity and neurodegeneration. These are, among others: gene encoding glucocorticoid receptor, FK506 binding protein 5 gene (FKBP5), gene encoding arginine vasopressin and oestrogen receptor alpha, 5-hydroxy-tryptamine transporter gene (SLC6A4), and gene encoding brain-derived neurotrophic factor. How about personality? Can the experiences unique to every human being, the history of his or her development and gene-environment interactions, through epigenetic mechanisms, shape the features of our personality? Can we pass on these features to future generations? Hence, is the risk of depression inherent in our biological nature? Can we change our destiny?
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.