Evidence map›Paper›PMID 32373270›Full record

ArticleThe Neurohospitalist2020

Rheumatoid Meningitis: Clinical Characteristics, Diagnostic Evaluation, and Treatment.

Angela M Parsons, Fawad Aslam, Marie F Grill, Allen J Aksamit, Brent P Goodman

Open access · greenAbstract read
In one paragraph

Article in The Neurohospitalist, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 27 citations in OpenAlex.

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  6. Rheumatoid meningitis: a case series report and review of modern therapeutic schemes and outcome.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
    Review
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  11. Rheumatoid Arthritis: A Rare Cause of Pachymeningitis and Optic Neuritis.European journal of case reports in internal medicine · 2024
    Article
  12. Non-infectious encephalopathy with recurrent stroke-like episodes: a case of rheumatoid meningitis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Angela M ParsonsDepartment of Neurology, Mayo Clinic, Scottsdale, AZ, USA.ORCID https://orcid.org/0000-0002-0506-894X
Fawad AslamDivision of Rheumatology, Mayo Clinic, Scottsdale, AZ, USA.
Marie F GrillDepartment of Neurology, Mayo Clinic, Scottsdale, AZ, USA.
Allen J AksamitDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
Brent P GoodmanDepartment of Neurology, Mayo Clinic, Scottsdale, AZ, USA.
Mayo Clinic in Arizona · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeDue to the potential for high mortality and neurologic complications of rheumatoid meningitis (RM), awaiting biopsy confirmation may delay vital treatment intervention. Our aim was to describe the clinical presentations of RM in our population and determine whether meningeal biopsy impacted diagnosis, treatment, and outcomes.

methodsA retrospective chart review was completed for patients at Mayo Clinic with a diagnosis of RM within the last 28 years. Those with identified alternative inflammatory, infectious, or neoplastic causes of pachymeningitis or leptomeningitis were excluded.

resultsFourteen patients meeting inclusion/exclusion criteria were identified. All patients were positive for rheumatoid factor or cyclic citrullinated peptide. All patients had magnetic resonance imaging abnormalities characterized by pachymeningeal and/or leptomeningeal enhancement. Of the 10 patients who underwent biopsy, nonspecific findings were seen in 74%. All patients except one were treated with corticosteroids with subsequent symptomatic improvement. Radiographic improvement or resolution was seen in 10 (83%) of 12. Patients improved with corticosteroid treatment, including those who were diagnosed with RM on clinical basis without undergoing a biopsy as well.

conclusionsThis retrospective review displays the myriad of clinical presentations of RM. It also suggests that with appropriate exclusion of infectious, neoplastic, and other autoimmune etiologies, biopsy may not be necessary to initiate treatment.

Indexed as

biopsyrheumatoid arthritisrheumatoid meningitisrheumatoid pachymeningitis

Identifiers

PMID32373270
PMCPMC7191662
OpenAlexW2955405924

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.