Evidence map›Paper›PMID 32373217›Full record

ArticleTheranostics2020

C-Met targeted fluorescence molecular endoscopy in Barrett's esophagus patients and identification of outcome parameters for phase-I studies.

Steven J de Jongh, Floris J Voskuil, Iris Schmidt, Arend Karrenbeld, Gursah Kats-Ugurlu, Gert Jan Meersma, Jessie Westerhof, Max J H Witjes, Gooitzen M van Dam, Dominic J Robinson and 1 more

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 31 citations in OpenAlex.

  1. Trial
  2. Targeted Fluorescence Imaging of Bevacizumab-800CW in Patients with Neovascular Age-Related Macular Degeneration.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Trial
  3. Review
  4. Review
  5. Article
  6. Fluorescence Imaging of Cancer.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2026
    Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Targeting c-MET for Endoscopic Detection of Dysplastic Lesions within Barrett's Esophagus Using EMI-137 Fluorescence Imaging.Clinical cancer research : an official journal of the American Association for Cancer Research · 2025
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Evaluation of [Pharmaceutics · 2023
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Steven J de JonghDepartment of Gastroenterology and Hepatology, University Medical Center Groningen, Groningen, The Netherlands.
Floris J VoskuilDepartment of Oral and Maxillofacial Surgery, University Medical Center Groningen, Groningen, The Netherlands.
Iris SchmidtDepartment of Gastroenterology and Hepatology, University Medical Center Groningen, Groningen, The Netherlands.
Arend KarrenbeldDepartment of Pathology, University Medical Center Groningen, Groningen, The Netherlands.
Gursah Kats-UgurluDepartment of Pathology, University Medical Center Groningen, Groningen, The Netherlands.
Gert Jan MeersmaDepartment of Gastroenterology and Hepatology, University Medical Center Groningen, Groningen, The Netherlands.
Jessie WesterhofDepartment of Gastroenterology and Hepatology, University Medical Center Groningen, Groningen, The Netherlands.
Max J H WitjesDepartment of Oral and Maxillofacial Surgery, University Medical Center Groningen, Groningen, The Netherlands.
Gooitzen M van DamDepartment of Surgery and Medical Imaging Center, University Medical Center Groningen, The Netherlands.
Dominic J RobinsonCenter for Optical Diagnostics and Therapy, Department of Otorhinolaryngology and Head and Neck Surgery, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.
Wouter B NagengastDepartment of Gastroenterology and Hepatology, University Medical Center Groningen, Groningen, The Netherlands.
University Medical Center Groningen · NLUniversité Claude Bernard Lyon 1 · FRHospices Civils de Lyon · FRLaboratoire CarMeN · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fluorescence molecular endoscopy (FME) is an emerging technique in the field of gastroenterology that holds potential to improve diagnosis and guide therapy, by serving as a 'red-flag' endoscopic imaging technique. Here, we investigated the safety, feasibility and optimal method of administration of EMI-137, targeting c-Met, during FME in Barrett's Esophagus (BE) and report several outcome parameters for early phase FME studies.

Indexed as

AgedBarrett EsophagusBiopsyEsophageal NeoplasmsFemaleHumansMaleMiddle AgedProspective StudiesProto-Oncogene Proteins c-metProto-Oncogene Proteins c-metBarrett's esophagusEMI-137 targeting c-Met.standardized fluorescence molecular endoscopy methodologyStructured roadmap

Identifiers

PMID32373217
PMCPMC7196285
OpenAlexW3015498512

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.