Evidence map›Paper›PMID 32373204›Full record

ArticleAsian journal of pharmaceutical sciences2020

The influence of genetic polymorphisms in drug metabolism enzymes and transporters on the pharmacokinetics of different fluvastatin formulations.

Qian Xiang, Weidang Wu, Nan Zhao, Chuan Li, Junyu Xu, Lingyue Ma, Xiaodan Zhang, Qiufen Xie, Zhuo Zhang, Jiancheng Wang and 3 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Asian journal of pharmaceutical sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Qian XiangDepartment of Pharmacy, Peking University First Hospital, Beijing 100034, China.
Weidang WuState Key Laboratory of Drug Release Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin 300193,China.
Nan ZhaoDepartment of Pharmacy, Peking University First Hospital, Beijing 100034, China.
Chuan LiState Key Laboratory of Drug Release Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin 300193,China.
Junyu XuDepartment of Pharmacy, Peking University First Hospital, Beijing 100034, China.
Lingyue MaDepartment of Pharmacy, Peking University First Hospital, Beijing 100034, China.
Xiaodan ZhangDepartment of Pharmacy, Peking University First Hospital, Beijing 100034, China.
Qiufen XieDepartment of Pharmacy, Peking University First Hospital, Beijing 100034, China.
Zhuo ZhangDepartment of Pharmacy, Peking University First Hospital, Beijing 100034, China.
Jiancheng WangSchool of Pharmaceutical Science, Peking University, Beijing 100191, China.
Weiren XuState Key Laboratory of Drug Release Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin 300193,China.
Xia ZhaoDepartment of Pharmacy, Peking University First Hospital, Beijing 100034, China.
Yimin CuiDepartment of Pharmacy, Peking University First Hospital, Beijing 100034, China.
Peking University · CNPeking University First Hospital · CNTianjin Institute of Pharmaceutical Research (China) · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The purpose of the present study was to investigate the impact of genetic polymorphism on fluvastatin pharmacokinetics. In addition, we compared the fluvastatin pharmacokinetics differences between extended-release (ER) 80 mg tablet and immediate-release (IR) 40 mg capsule in terms of drug metabolism enzyme and transporter genetic polymorphisms. In this open-label, randomized, two-period, two-treatment, crossover study (

Indexed as

Extended-releaseFluvastatinGenetic polymorphismsImmediate-releaseSLCO1B1

Identifiers

PMID32373204
PMCPMC7193447
OpenAlexW2966716148

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.