Evidence map›Paper›PMID 32373183›Full record

ReviewDrugs in context2020

Chloroquine and hydroxychloroquine in the context of COVID-19.

Ashutosh M Shukla, Lennox K Archibald, Aparna Wagle Shukla, Hiren J Mehta, Kartikeya Cherabuddi

Open access · goldAbstract readReview
In one paragraph

Review in Drugs in context, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 52 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Drugs that Might Be Possibly Used for Treatment of COVID-19 Patients.Russian journal of bioorganic chemistry · 2021
    Article
  8. Approaches towards fighting the COVID‑19 pandemic (Review).International journal of molecular medicine · 2021
    Review
  9. Review
  10. Review
  11. Article
  12. Why PB28 Could Be a Covid 2019 Game Changer?ACS medicinal chemistry letters · 2020
    Article
  13. Opportunities for biomaterials to address the challenges of COVID-19.Journal of biomedical materials research. Part A · 2020
    Review
  14. Review
  15. Article
  16. Review
  17. A Case Control Study to Evaluate the Impact of Colchicine on Patients Admitted to the Hospital with Moderate to Severe COVID-19 Infection.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Ashutosh M ShuklaNorth Florida South Georgia VHS, Gainesville, FL, USA.
Lennox K ArchibaldNorth Florida South Georgia VHS, Gainesville, FL, USA.
Aparna Wagle ShuklaDepartment of Neurology, University of Florida, Gainesville, FL, USA.
Hiren J MehtaDepartment of Medicine, University of Florida, Gainesville, FL, USA.
Kartikeya CherabuddiDepartment of Medicine, University of Florida, Gainesville, FL, USA.
University of Florida · USNorth Florida/South Georgia Veterans Health System · US

Funding

Functional Brain Networks in Essential Tremor and Dystonic TremorK23NS092957 · NINDS · UNIVERSITY OF FLORIDA · PI WAGLE SHUKLA, APARNA · 2016 to 2019
$703k
Hydroxychloroquine for the Management of CVD in CKDI01CX001661 · VA · VETERANS HEALTH ADMINISTRATION · PI MARK S. SEGAL, Ashutosh M Shukla · 2019 to 2026
–
A Patient-centered, System-based Approach to Improve Informed Dialysis Choice and Outcomes in Veterans with CKDI01HX002639 · VA · VETERANS HEALTH ADMINISTRATION · PI JIA, HUANGUANG, SHUKLA, ASHUTOSH M · 2020 to 2025
–
CSRD VA I01 CX001661HSRD VA I01 HX002639NINDS NIH HHS K23 NS092957
6 · The paper itself

Abstract

Chloroquine and closely related structural analogs, employed initially for the treatment of malaria, are now gaining worldwide attention due to the rapidly spreading pandemic caused by severe acute respiratory syndrome-coronavirus-2, named coronavirus disease (COVID) of 2019 (COVID-19). Although much of this attention has a mechanistic basis, the hard efficacy data for chloroquine/hydroxychloroquine in the management of the clinical syndrome of COVID-19 have been limited thus far. This review aims to present the available

Indexed as

anti-inflammatoryantimalarialantiviralchloroquineCOVID-19hydroxychloroquineimmunomodulatorypandemicSARS-CoV-2

Identifiers

PMID32373183
PMCPMC7192209
OpenAlexW3018902251

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.