ArticleFrontiers in genetics2020
A Between Ethnicities Comparison of Chronic Obstructive Pulmonary Disease Genetic Risk.
Article in Frontiers in genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- The impact of Shanghai's comprehensive smoke-free legislation on hospital admission and mortality rates for chronic obstructive pulmonary disease: an interrupted time series analysis.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2026Article
- Genetic architecture of human aging and longevity: Insights from genome-wide association studies.BMB reports · 2026Review
- Diversity and inclusivity in clinical trial populations for maintenance inhaler therapy in people with COPD: a systematic review.ERJ open research · 2026Article
- Article
- Screening the Best Risk Model and Susceptibility SNPs for Chronic Obstructive Pulmonary Disease (COPD) Based on Machine Learning Algorithms.International journal of chronic obstructive pulmonary disease · 2024Article
- Prediction and stratification of longitudinal risk for chronic obstructive pulmonary disease across smoking behaviors.Nature communications · 2023Article
- De novo discovery of traits co-occurring with chronic obstructive pulmonary disease.Life science alliance · 2023Article
- Particle radioactivity from radon decay products and reduced pulmonary function among chronic obstructive pulmonary disease patients.Environmental research · 2023Article
- Polygenic scores for low lung function and the future risk of adverse health outcomes.Cardiovascular diabetology · 2022Article
- Role of an unclassified Lachnospiraceae in the pathogenesis of type 2 diabetes: a longitudinal study of the urine microbiome and metabolites.Experimental & molecular medicine · 2022Article
- Genetic Factors Associated with COPD Depend on the Ancestral Caucasian/Amerindian Component in the Mexican Population.Diagnostics (Basel, Switzerland) · 2021Article
- Understanding racial differences of COPD patients with an ecological model: two large cohort studies in the US and Korea.Therapeutic advances in chronic disease · 2021Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Heterogeneity of lung function levels and risk for developing chronic obstructive pulmonary disease (COPD) among people exposed to the same environmental risk factors, such as cigarette smoking, suggest an important role of genetic factors in COPD susceptibility. To investigate the possible role of different genetic factors in COPD susceptibility across ethnicities. We used a population-stratified analysis for: (i) identifying ethnic-specific genetic susceptibility loci, (ii) developing ethnic-specific polygenic risk prediction models using those SNPs, and (iii) validating the models with an independent dataset. We elucidated substantial differences in SNP heritability and susceptibility loci for the disease across ethnicities. Furthermore, the application of three ethnic-specific prediction models to an independent dataset showed that the best performance is achieved when the prediction model is applied to a dataset with the matched ethnic sample. Our study validates the necessity of considering ethnic differences in COPD risk; understanding these differences might help in preventing COPD and developing therapeutic strategies.
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