ArticleFrontiers in genetics2020
Identifying Shared Risk Genes for Asthma, Hay Fever, and Eczema by Multi-Trait and Multiomic Association Analyses.
Article in Frontiers in genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Educational and psychological interventions for managing atopic dermatitis (eczema).The Cochrane database of systematic reviews · 2024Pooled it
- The Immunogenetic Landscape of Allergic Rhinitis: from Cellular Effectors to Gene Regulation and Targeted Therapies.International journal of biological sciences · 2026Review
- Shared loci but distinct variants underlie genetic architecture of allergic diseases.medRxiv : the preprint server for health sciences · 2025Article
- Joint genotype and ancestry analysis identify novel loci associated with atopic dermatitis in African American population.HGG advances · 2024Article
- Pyroptosis, gasdermins and allergic diseases.Allergy · 2024Review
- Asthma-Genomic Advances Toward Risk Prediction.Clinics in chest medicine · 2024Review
- Genetic and Immunological Pathogenesis of Atopic Dermatitis.The Journal of investigative dermatology · 2024Review
- Revealing polygenic pleiotropy using genetic risk scores for asthma.HGG advances · 2023Article
- Genomics of Treatable Traits in Asthma.Genes · 2023Review
- Integrating eQTL and GWAS data characterises established and identifies novel migraine risk loci.Human genetics · 2023Article
- Allergy: Mechanistic insights into new methods of prevention and therapy.Science translational medicine · 2023Review
- A genome-wide cross-cancer meta-analysis highlights the shared genetic links of five solid cancers.Frontiers in microbiology · 2023Article
- Multi-ancestry meta-analysis of asthma identifies novel associations and highlights the value of increased power and diversity.Cell genomics · 2022Article
- Genome-wide imputed differential expression enrichment analysis identifies trait-relevant tissues.Frontiers in genetics · 2022Article
- Organic Food Consumption During the Complementary Feeding Period and Respiratory or Allergic Diseases Up to Age 5.5 Years in the ELFE Cohort.Frontiers in nutrition · 2021Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Asthma, hay fever and eczema are three comorbid diseases with high prevalence and heritability. Their common genetic architectures have not been well-elucidated. In this study, we first conducted a linkage disequilibrium score regression analysis to confirm the strong genetic correlations between asthma, hay fever and eczema. We then integrated three distinct association analyses (metaCCA multi-trait association analysis, MAGMA genome-wide and MetaXcan transcriptome-wide gene-based tests) to identify shared risk genes based on the large-scale GWAS results in the GeneATLAS database. MetaCCA can detect pleiotropic genes associated with these three diseases jointly. MAGMA and MetaXcan were performed separately to identify candidate risk genes for each of the three diseases. We finally identified 150 shared risk genes, in which 60 genes are novel. Functional enrichment analysis revealed that the shared risk genes are enriched in inflammatory bowel disease, T cells differentiation and other related biological pathways. Our work may provide help on treatment of asthma, hay fever and eczema in clinical applications.
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