Evidence map›Paper›PMID 32373117›Full record

ArticleFrontiers in immunology2020

Bacteria-Induced Acute Inflammation Does Not Reduce the Long-Term Reconstitution Capacity of Bone Marrow Hematopoietic Stem Cells.

Xiaoyu Zhang, Kutay Karatepe, Direkrit Chiewchengchol, Haiyan Zhu, Rongxia Guo, Peng Liu, Hongbo Yu, Qian Ren, Xiao Luo, Tao Cheng and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 2 countries.

Xiaoyu ZhangDepartment of Pathology, Harvard Stem Cell Institute (HSCI), Harvard Medical School, Boston, MA, United States.
Kutay KaratepeDepartment of Pathology, Harvard Stem Cell Institute (HSCI), Harvard Medical School, Boston, MA, United States.
Direkrit ChiewchengcholDepartment of Pathology, Harvard Stem Cell Institute (HSCI), Harvard Medical School, Boston, MA, United States.
Haiyan ZhuThe State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China.
Rongxia GuoThe State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China.
Peng LiuThe State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China.
Hongbo YuDepartment of Pathology and Laboratory Medicine, VA Boston Healthcare System, West Roxbury, MA, United States.
Qian RenThe State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China.
Xiao LuoDepartment of Pathology, Harvard Stem Cell Institute (HSCI), Harvard Medical School, Boston, MA, United States.
Tao ChengThe State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China.
Fengxia MaThe State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China.
Yuanfu XuThe State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China.
Mingzhe HanDepartment of Hematopoietic Stem Cell Transplantation, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China.
Hongbo R LuoDepartment of Pathology, Harvard Stem Cell Institute (HSCI), Harvard Medical School, Boston, MA, United States.
Chinese Academy of Medical Sciences & Peking Union Medical College · CNHarvard Stem Cell Institute · USHarvard University · USDana-Farber/Harvard Cancer Center · USInstitute of Hematology & Blood Diseases Hospital · CNVA Boston Healthcare System · US

Funding

Transcription regulation in hematopoiesisP01HL095489 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI PARK, SHINYOUNG · 2010 to 2020
$20.1M
Enhancing neutrophil function in neutropenia-related pneumoniaR01HL092020 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI LUO, HONGBO R · 2009 to 2022
$5.2M
Regulation of neutrophil death by GSDMD in Candida albicans infectionR01AI145274 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI LUO, HONGBO R · 2019 to 2023
$2.2M
Regulation of IL-1β bioactivity by Cysteine S-glutathionylationR01AI142642 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI LUO, HONGBO R · 2019 to 2023
$2.2M
Cell-based high-throughput chemical genetic screening for GSDMD inhibitorsR01AI141386 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI LUO, HONGBO R · 2019 to 2022
$1.8M
NHLBI NIH HHS P01 HL095489NHLBI NIH HHS R01 HL092020NIAID NIH HHS R01 AI141386NIAID NIH HHS R01 AI142642NIAID NIH HHS R01 AI145274
6 · The paper itself

Abstract

Pathogen-initiated chronic inflammation or autoimmune diseases accelerate proliferation and promote differentiation of hematopoietic stem cells (HSCs) but simultaneously reduce reconstitution capacity. Nevertheless, the effect of acute infection and inflammation on functional HSCs is still largely unknown. Here we found that acute infection elicited by heat-inactivated

Indexed as

Acute DiseaseAnimalsBone Marrow CellsCell DifferentiationCells, CulturedCell Self RenewalEscherichia coliEscherichia coli InfectionsHematopoietic Stem CellsHematopoietic Stem Cell TransplantationHumansInflammationMiceMice, Inbred C57BLTransplantation Chimeraacute infectionhematopoietic stem cellsinflammationlong-term reconstitutionself-renewal

Identifiers

PMID32373117
PMCPMC7179742
OpenAlexW3016900396

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.