ArticleCirculation. Arrhythmia and electrophysiology2020
Pulsed Field Ablation Using a Lattice Electrode for Focal Energy Delivery: Biophysical Characterization, Lesion Durability, and Safety Evaluation.
Article in Circulation. Arrhythmia and electrophysiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06364215 (Posterior Wall Substrate Modification Using Irreversible Electroporation for the Treatment of Paroxysmal Atrial Fibrillation), which is not on this map. Cited by 41 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Posterior Wall Substrate Modification Using Irreversible Electroporation for the Treatment of Paroxysmal Atrial Fibrillation
Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.
- Pulsed field ablation for atrial fibrillation: a comprehensive bibliometric analysis of research trends and emerging Frontiers.Frontiers in cardiovascular medicine · 2025Pooled it
- Dual-energy lattice-tip ablation system for persistent atrial fibrillation: a randomized trial.Nature medicine · 2024Trial
- First-in-human clinical series of a novel conformable large-lattice pulsed field ablation catheter for pulmonary vein isolation.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024Trial
- Unintended right atrial lesions after monopolar biphasic lattice-tip pulsed-field ablation: a case series.European heart journal. Case reports · 2026Article
- Pulsed Field Ablation with the Pentaspline Catheter vs Radiofrequency Ablation for Recurrent Atrial Fibrillation.CJC open · 2026Article
- Pulsed Field Ablation Is Associated With Fewer Post-Procedural Pericardial Inflammatory Symptoms Compared With Radiofrequency Ablation.Journal of cardiovascular electrophysiology · 2026Observational
- Multi-modality imaging assessment of microbubbles and cerebral emboli in left ventricular pulsed field ablation.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026Article
- Multi-modality imaging assessment of microbubbles and cerebral emboli in left ventricular pulsed field ablation.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026Article
- Pulsed electric field for pulmonary vein isolation in paroxysmal atrial fibrillation: A multicenter experience comparing pentaspline and lattice-tip catheters.Heart rhythm O2 · 2026Article
- Epicardial tissue heating during pulsed field ablation assessed using a novel experimental model: implications for collateral damage.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026Article
- Same day discharge can be performed safely after atrial fibrillation catheter ablation using a wide-footprint lattice-tip dual-energy system.Heart rhythm O2 · 2026Article
- Pulsed field ablation: focused on atrial fibrillation ablation.The Korean journal of internal medicine · 2026Review
- Article
- Electric field effects of pulsed field ablation through adjacent non-cardiac tissues in anFrontiers in cardiovascular medicine · 2026Article
- Sex differences in procedural characteristics, safety, and clinical outcomes of pulsed field ablation for atrial fibrillation.Heart rhythm O2 · 2026Article
- Lesion Formation in Cardiac Pulsed-Field Ablation: Acute to Chronic Cellular Level Changes.Pacing and clinical electrophysiology : PACE · 2026Review
- Efficacy of Peak Frequency in Pulmonary Vein Isolation Using Pulsed Field Ablation for Atrial Fibrillation.Journal of cardiovascular electrophysiology · 2025Article
- P-Wave Parameter Changes After Pulsed-Field Ablation, Cryoballoon Ablation and Radiofrequency Ablation for Paroxysmal Atrial Fibrillation: An Observational Cohort Study.Journal of arrhythmia · 2025Article
- Exploratory Study of the Effects of Irreversible Electroporation on Atherosclerotic Plaque in a Rabbit Model.Journal of cardiovascular translational research · 2025Article
- Near-zero fluoroscopy workflow for pulmonary vein isolation in atrial fibrillation using a variable loop, 3D-integrated circular PFA catheter (Varipulse™): initial single-center experience with the first 35 patients.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2025Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundPulsed field ablation (PFA) is a nonthermal energy that may provide safety advantages over radiofrequency ablation (RFA). One-shot PFA catheters have been developed for pulmonary vein isolation, but they do not permit flexible lesion sets. This study investigated a novel lattice-tip catheter designed for focal RFA or PFA ablation.
methodsThe effects of PFA (biphasic, 24 amperes) were investigated in 25 swine using a lattice-tip catheter and system (Affera Inc). Step 1 (n=14) examined the feasibility to create atrial line of block and described its acute effects on the phrenic nerve and esophagus. Step 2 (n=7) examined the subacute effects of PFA on block durability, phrenic nerve, and esophagus ≥2 weeks. Step 3 compared the effects of PFA and RFA on the esophagus using a mechanical deviation model approximating the esophagus to the right atrium (n=4) and by direct ablation within its lumen (n=4). The effects of endocardial PFA and RFA on the phrenic nerve were also compared (n=10). Histological analysis was performed.
resultsPFA produced acute block in 100% of lines, achieved with 2.1 (1.3-3.2) applications/cm line. Histological analysis following (35 [18-37]) days showed 100% transmurality (thickness range 0.4-3.4 mm) with a lesion width of 19.4 (10.9-27.4 mm). PFA selectively affected cardiomyocytes but spared blood vessels and nervous tissue. PFA applied from the posterior atria (23 [21-25] applications) to the approximated esophagus (6 [4.5-14] mm) produced transmural lesions without esophageal injury. PFA (16.5 [15-18] applications) applied inside the esophageal lumen produced mild edema compared with RFA (13 [12-14] applications) which produced epithelial ulcerations. PFA resulted in no or transient stunning of the phrenic nerve (<5 minutes) without histological changes while RFA produced paralysis.
conclusionsPFA using a lattice-tip ablation catheter for focal ablation produced durable atrial lesions and showed lower vulnerability to esophageal or phrenic nerve damage compared with RFA.
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