ArticleJournal of biomedical optics2020
Heartbeat OCE: corneal biomechanical response to simulated heartbeat pulsation measured by optical coherence elastography.
Article in Journal of biomedical optics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 44 citations in OpenAlex.
- Depth-Resolved Attenuation Coefficient Quantification During Murine Embryonic Brain Development.Journal of biophotonics · 2025Article
- Analysis of pulsatile motion in the murine cornea using phase-sensitive visible-light optical coherence tomography.Biomedical optics express · 2025Article
- Convolutional Neural Networks Enable Direct Strain Estimation in Quasistatic Optical Coherence Elastography.Journal of biophotonics · 2025Article
- Assessing UVA and Laser-Induced Crosslinking via Brillouin Microscopy.Journal of biophotonics · 2025Article
- In-vivo high-frequency quantitative ultrasound-derived parameters of the anterior sclera correlated with level of myopia and presence of staphyloma.Clinical & experimental ophthalmology · 2024Article
- Asynchronous, semi-reverberant elastography.Optica · 2024Article
- Acute alcohol consumption modulates corneal biomechanical properties as revealed by optical coherence elastography.Journal of biomechanics · 2024Article
- Full-field noise-correlation elastography for in-plane mechanical anisotropy imaging.Biomedical optics express · 2024Article
- Optical coherence elastography measures the biomechanical properties of theJournal of biomedical optics · 2024Article
- Corneal Surface Wave Propagation Associated with Intraocular Pressures: OCT Elastography Assessment in a Simplified Eye Model.Bioengineering (Basel, Switzerland) · 2023Article
- Recent advances in optical elastography and emerging opportunities in the basic sciences and translational medicine [Invited].Biomedical optics express · 2023Review
- Multiple Optical Elastography Techniques Reveal the Regulation of Corneal Stiffness by Collagen XII.Investigative ophthalmology & visual science · 2022Article
- Optical coherence elastography for assessing the influence of intraocular pressure on elastic wave dispersion in the cornea.Journal of the mechanical behavior of biomedical materials · 2022Article
- Wave-based optical coherence elastography: The 10-year perspective.Progress in biomedical engineering (Bristol, England) · 2022Article
- Multimodal Heartbeat and Compression Optical Coherence Elastography for Mapping Corneal Biomechanics.Frontiers in medicine · 2022Article
- Enhanced medical diagnosis for dOCTors: a perspective of optical coherence tomography.Journal of biomedical optics · 2021Review
- Regional variation of corneal stromal deformation measured by high-frequency ultrasound elastography.Experimental biology and medicine (Maywood, N.J.) · 2021Article
- Compressional Optical Coherence Elastography of the Cornea.Photonics · 2021Article
- Heartbeat optical coherence elastography: corneal biomechanics in vivo.Journal of biomedical optics · 2021Article
- A review of corneal biomechanics: Mechanisms for measurement and the implications for refractive surgery.Indian journal of ophthalmology · 2020Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
significanceIt is generally agreed that the corneal mechanical properties are strongly linked to many eye diseases and could be used to assess disease progression and response to therapies. Elastography is the most notable method of assessing corneal mechanical properties, but it generally requires some type of external excitation to induce a measurable displacement in the tissue.
aimWe present Heartbeat Optical Coherence Elastography (Hb-OCE), a truly passive method that can measure the elasticity of the cornea based on intrinsic corneal displacements induced by the heartbeat. APPROACH: Hb-OCE measurements were performed in untreated and UV-A/riboflavin cross-linked porcine corneas ex vivo, and a distinct difference in strain was detected. Furthermore, a partially cross-linked cornea was also assessed, and the treated and untreated areas were similarly distinguished.
resultsOur results suggest that Hb-OCE can spatially map displacements in the cornea induced by small fluctuations in intraocular pressure, similar to what is induced by the heartbeat.
conclusionsThe described technique opens the possibility for completely passive and noncontact in vivo assessment of corneal stiffness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.