Evidence map›Paper›PMID 32372513›Full record

ArticleJournal of clinical laboratory analysis2020

Clinical value of seven autoantibodies combined detection in the diagnosis of lung cancer.

Yinyu Mu, Fuyi Xie, Tingting Sun

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical laboratory analysis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Autoimmune Responses in Oncology: Causes and Significance.International journal of molecular sciences · 2021
    Review
  11. Article
  12. Article
  13. [Research Progress on Lung Cancer Screening].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2020
    Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Yinyu MuDepartment of Clinical laboratory, Ningbo Medical Center, Li Huili Hospital, Ningbo, China.ORCID https://orcid.org/0000-0003-1239-2761
Fuyi XieDepartment of Clinical laboratory, Ningbo Medical Center, Li Huili Hospital, Ningbo, China.
Tingting SunDepartment of Clinical laboratory, Ningbo Medical Center, Li Huili Hospital, Ningbo, China.
Ningbo Medical Center Lihuili Hospital · CN

Funding

Medical and Health Planned Science and Technology Project of Zhejiang Province 2018KY158Medical and Health Planned Science and Technology Project of Zhejiang Province 2019KY606Nature Science Foundation of Ningbo City 2019A610230
6 · The paper itself

Abstract

backgroundTo analyze the clinical value of seven autoantibodies (p53, PGP9.5, SOX2, GAGE7, GBU4-5, MAGE A1 and CAGE) in lung cancer patients.

methodsELISA was used to determine serum levels of seven autoantibodies in 177 patients with lung cancer, 201 healthy persons, and 210 patients with benign pulmonary diseases. Positive rates of 7 autoantibodies were analyzed; receiver operating characteristic (ROC) curves were drawn to analyze their diagnostic efficiency in lung cancer and to compare the positive rate of seven kinds of autoantibody combined detection of lung cancer patients with different clinicopathological features.

resultsThe positive rate of seven autoantibodies in all subjects was 13.44%. The positive rate of seven autoantibodies in lung cancer was 25.42%. The positive rate of the combined detection of seven autoantibodies in the lung cancer group was significantly higher than that in healthy control group (χ

conclusionsThe combined detection of 7 autoantibodies in lung cancer has some clinical value for the auxiliary diagnosis of lung cancer.

Indexed as

Lung NeoplasmsAdultAgedAged, 80 and overAutoantibodiesBiomarkers, TumorEnzyme-Linked Immunosorbent AssayFemaleHumansMaleMiddle AgedSensitivity and SpecificityYoung AdultAutoantibodiesBiomarkers, Tumorautoantibodyclinical valuecombined detectiondiagnosislung cancer

Identifiers

PMID32372513
PMCPMC7439340
OpenAlexW3022881879

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.