ArticleThe Journal of physiology2020
Kir6.1-dependent K
Open access · greenAbstract read
In one paragraph
Article in The Journal of physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
6.7field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 59 citations in OpenAlex.
- Cantú Syndrome: A Poorly Understood Multi-Organ Disorder.International journal of molecular sciences · 2026Review
- Dysfunctional adipose tissue-lymphatic crosstalk in obesity.Nature reviews. Endocrinology · 2026Review
- GLP-1 Receptors Are Enriched in the Lymphatic Endothelium and Their Pharmacological Activation With Semaglutide Improves the Pumping Capacity of Lymphatic Vessels.Microcirculation (New York, N.Y. : 1994) · 2026Article
- Pacemaking in the lymphatic system.The Journal of physiology · 2026Review
- Venous Tone is a Critical Determinant of Venous Valve Closure in the Mouse.Function (Oxford, England) · 2025Article
- Roles of G-protein coupled receptors and mechanosensitive ion channels in pressure-induced chronotropy of lymphatic vessels.bioRxiv : the preprint server for biology · 2025Article
- Moving toward a better understanding of renal lymphatics: challenges and opportunities.Pediatric nephrology (Berlin, Germany) · 2025Review
- Article
- Regulation of Collecting Lymphatic Vessel Contractile Function by TRPV4 Channels.Arteriosclerosis, thrombosis, and vascular biology · 2025Article
- Article
- Bayliss-Starling Prize Lecture: KThe Journal of physiology · 2025Article
- Chronic metabolic stress impairs lymphatic contractility via activation of KATP channels in a mouse model of Type-2 diabetes.Frontiers in physiology · 2025Article
- Gain-of-function mutations in KATP channel subunits compromise colonic tight junction integrity and epithelial homeostasis in murine models of Cantú syndrome.Frontiers in medicine · 2025Article
- A novel ABCC9 variant in a Greek family with Cantu syndrome affecting multiple generations highlights the functional role of the SUR2B NBD1.American journal of medical genetics. Part A · 2024Article
- Acute Metabolic Stress Induces Lymphatic Dysfunction Through KATP Channel Activation.Function (Oxford, England) · 2024Article
- Connexin-45 is expressed in mouse lymphatic endothelium and required for lymphatic valve function.JCI insight · 2024Article
- Loss of anoctamin 1 reveals a subtle role for BK channels in lymphatic muscle action potentials.The Journal of physiology · 2024Article
- Novel loss-of-function variants expand ABCC9-related intellectual disability and myopathy syndrome.Brain : a journal of neurology · 2024Article
- Article
- Do KFrontiers in immunology · 2024Review
Corrections and comments
- Commented on by
Authors and funding
11 authors at 2 institutions in 1 country.
Michael J DavisDepartment of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia, MO, 65212, USA.ORCID 0000-0002-7992-9300
Hae Jin KimDepartment of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia, MO, 65212, USA.
Scott D ZawiejaDepartment of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia, MO, 65212, USA.
Jorge A Castorena-GonzalezDepartment of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia, MO, 65212, USA.ORCID 0000-0001-5252-375X
Peichun GuiDepartment of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia, MO, 65212, USA.
Min LiDepartment of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia, MO, 65212, USA.
Brian T SaundersDepartment of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, 63110, USA.
Bernd H ZinselmeyerDepartment of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, 63110, USA.
Gwendalyn J RandolphDepartment of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, 63110, USA.
Maria S RemediDepartment of Medicine, Washington University School of Medicine, St Louis, MO, 63110, USA.
Colin G NicholsDepartment of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO, 63110, USA.ORCID 0000-0002-4929-2134
University of Missouri · USWashington University in St. Louis · US
Funding
Role of vascular KATP channels in Alzheimer’s neurodegeneration and dementiaR35HL140024 · NHLBI · WASHINGTON UNIVERSITY · PI NICHOLS, COLIN G · 2018 to 2023
$5.9MLymphatic pacemaking and pumping in lymphedema: function, dysfunction, and rescueR01HL122578 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI DAVIS, MICHAEL JOHN · 2015 to 2023
$4.1MKATP channels and lymphatic dysfunction in Cantu SyndromeR01HL141107 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI DAVIS, MICHAEL JOHN · 2018 to 2021
$1.5MEndothelial dependent mechanisms of lymphatic dysfunction in metabolic syndrome and type-2 diabetes associated with obesityR00HL141143 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI CASTORENA, JORGE AUGUSTO · 2020 to 2022
$746kThe Regulation of Lymphatic Muscle Cell Pacemaking by Intracellular Calcium SignalsK99HL143198 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI ZAWIEJA, SCOTT D. · 2019 to 2020
$203kEndothelial dependent mechanisms of lymphatic dysfunction in metabolic syndrome and type-2 diabetes associated with obesityK99HL141143 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI CASTORENA, JORGE AUGUSTO · 2019 to 2020
$193kNHLBI NIH HHS K99 HL-141143NHLBI NIH HHS K99 HL141143NHLBI NIH HHS K99 HL143198NHLBI NIH HHS R00 HL141143NHLBI NIH HHS R01 HL-122578NHLBI NIH HHS R01 HL122578NHLBI NIH HHS R01 HL-122608NHLBI NIH HHS R01 HL141107NHLBI NIH HHS R35 HL140024NIGMS NIH HHS R35 HL-140024
Abstract
key pointsSpontaneous contractions are essential for normal lymph transport and these contractions are exquisitely sensitive to the K ABSTRACT: This study aimed to understand the functional expression of K
Indexed as
Gain of Function MutationHypertrichosisAdenosine TriphosphateAnimalsHumansKATP ChannelsMiceMice, Inbred C57BLMuscle, SmoothSulfonylurea ReceptorsAdenosine TriphosphateKATP ChannelsSulfonylurea Receptorscantú syndromeelectrophysiologylymphatic dysfunctionlymphedemapressure myography
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.