ArticleInfection2020
Outcome of spinal implant-associated infections treated with or without biofilm-active antibiotics: results from a 10-year cohort study.
Article in Infection, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Rifampin Based Therapy for Patients With Staphylococcus aureus Native Vertebral Osteomyelitis: A Systematic Review and Meta-analysis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024Pooled it
- Current therapeutic interventions combating biofilm-related infections in orthopaedics : a systematic review of in vivo animal studies.Bone & joint research · 2022Pooled it
- Long-term patient-reported outcomes and mechanical complications following spinal fusion in patients with surgical site infection managed with retained instrumentation versus non-infected patients: a systematic review and meta-analysis.Journal of spine surgery (Hong Kong) · 2026Article
- Clinical burden and treatment pathways of early deep surgical site infection after lumbar spine surgery: a Vietnamese single-center descriptive study.Journal of spine surgery (Hong Kong) · 2026Article
- Systemic immune responses in patients with spine surgery related infections.Frontiers in immunology · 2026Article
- Novel citrate-based wound irrigation system disrupting biofilms and preventing orthopaedic surgery infections: technique guide and systematic review.Journal of spine surgery (Hong Kong) · 2025Review
- Role of microbiota in pain: From bench to bedside.iMetaOmics · 2025Review
- In Vitro Bacterial Growth on Titanium Surfaces Treated with Nanosized Hydroxyapatite.Journal of functional biomaterials · 2025Article
- Risk-Adapted Use of Vancomycin in Secondary Scoliosis Surgery May Normalize SSI Risk in Surgical Correction of High-Risk Patients.Journal of personalized medicine · 2024Article
- Microbiological Profile of Instrumented Spinal Infections: 10-Year Study at a French Spine Center.Antibiotics (Basel, Switzerland) · 2024Article
- Synthesis and evaluation of a novel vancomycin-infused, biomimetic bone graft using a rat model of spinal implant-associated infection.North American Spine Society journal · 2024Article
- Efficacy of single antibiotic therapy versus antibiotic combination in implant-free staphylococcal post-surgical spinal infections: a retrospective observational study.BMC infectious diseases · 2024Observational
- Biofilm antimicrobial susceptibility testing: where are we and where could we be going?Clinical microbiology reviews · 2023Review
- A novel rodent model of chronic spinal implant-associated infection.The spine journal : official journal of the North American Spine Society · 2023Article
- Insights into the microbiological and virulence characteristics of bacteria in orthopaedic implant infections: A study from Pakistan.PloS one · 2023Article
- Review
- An ionic silver coating prevents implant-associated infection by anaerobic bacteria in vitro and in vivo in mice.Scientific reports · 2022Article
- Personalized bacteriophage therapy to treat pandrug-resistant spinal Pseudomonas aeruginosa infection.Nature communications · 2022Article
- Postoperative Spinal Implant Infections (PSII)-A Systematic Review: What Do We Know So Far and What is Critical About It?Global spine journal · 2022Article
- De novo methicillin-resistant Staphylococcus aureus vs. methicillin-sensitive Staphylococcus aureus infections of the spine, similar clinical outcome, despite more severe presentation in surgical patients.Neurosurgical review · 2021Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeBiofilm-active antibiotics are suggested to improve the outcome of implant-associated infections; however, their role in infections after spinal instrumentation is unclear. Therefore, we evaluated the outcome of patients with spinal implant-associated infections treated with and without biofilm-active antibiotics.
methodsThe probability of infection-free survival was estimated for treatment of spinal implant-associated infections with and without biofilm-active antibiotics using the Kaplan-Meier method; Cox proportional-hazards regression model was used to identify factors associated with treatment failure.
resultsAmong 93 included patients, early-onset infection was diagnosed in 61 (66%) and late-onset in 32 infections (34%). Thirty patients (32%) were treated with biofilm-active antibiotic therapy and 63 (68%) without it. The infection-free survival after a median follow-up of 53.7 months (range, 8 days-9.4 years) was 67% (95% confidence interval [CI], 55-82%) after 1 year and 58% (95% CI 43-71%) after 2 years. The infection-free survival after 1 and 2 years was 94% (95% CI 85-99%) and 84% (95% CI 71-93%) for patients treated with biofilm-active antibiotics, respectively, and 57% (95% CI 39-80%) and 49% (95% CI 28-61%) for those treated without biofilm-active antibiotics, respectively (p = 0.009). Treatment with biofilm-active antibiotics (hazard ratio [HR], 0.23, 95% CI 0.07-0.77), infection with Staphylococcus auras (HR, 2.19, 95% CI 1.04-4.62) and polymicrobial infection (HR, 2.44, 95% CI 1.09-6.04) were significantly associated with treatment outcome. Severe pain was observed more often in patients without biofilm-active antibiotic therapy (49% vs. 18%, p = 0.027).
conclusionTreatment with biofilm-active antibiotics was associated with better treatment outcome and less postoperative pain intensity.
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