ArticleJournal of the Egyptian National Cancer Institute2020
Anticancer effects induced by artichoke extract in oral squamous carcinoma cell lines.
Article in Journal of the Egyptian National Cancer Institute, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 28 citations in OpenAlex.
- Phenolic-Rich Extracts from Artichoke By-Products Promote Apoptosis in Human Colorectal Cancer Cell Lines.Nutrients · 2026Article
- Artichoke Extract Ameliorates CCl4-Induced Hepatocellular Carcinoma in Albino Rats by Regulating the Phosphatidylinositol 3-kinase/serine-threonine Protein Kinase Pathway.Anti-cancer agents in medicinal chemistry · 2026Article
- Molecular Targets of Plant-Derived Bioactive Compounds in Oral Squamous Cell Carcinoma.Cancers · 2024Review
- Diet and Oral Squamous Cell Carcinoma: A Scoping Review.International journal of environmental research and public health · 2024Article
- In Vitro Anticancer Activity of Mucoadhesive Oral Films Loaded withAntioxidants (Basel, Switzerland) · 2022Article
- Article
- Pro-Apoptotic Activity of Artichoke Leaf Extracts in Human HT-29 and RKO Colon Cancer Cells.International journal of environmental research and public health · 2021Article
- Food Bioactive Compounds and Emerging Techniques for Their Extraction: Polyphenols as a Case Study.Foods (Basel, Switzerland) · 2020Review
- Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOral squamous cell carcinoma is occupying the eighth position of all malignant neoplasia worldwide. Nowadays, natural compounds found in vegetables and fruits are important resources of many anticancer drugs especially those with high levels of phytochemicals representing an efficient strategy for cancer prevention and treatment. Artichoke (Cynara cardunculus L.) is a kind of antioxidant-rich vegetables demonstrated a potential anticancer activity on various types of cancer cells related to its content of phenolic compounds. Anticarcinogenic effects of polyphenolic extracts were reported to cause a reduction in cell viability, inhibition of cell growth, and initiation of apoptotic mechanisms. The present study aimed to investigate the cell cycle arrest, cytotoxic, and apoptotic effects of artichoke extract against the invasive oral squamous cell carcinoma.
resultsA pure extract from the edible part and leaves of fresh artichoke was added to oral squamous carcinoma cell lines and to control group to evaluate the expression of caspase-9, Bcl-2, and Bax genes. Artichoke extract demonstrated the highest cytotoxic effect against cancer cell lines which increased in a time-dependent manner. No apparent effects were observed in the normal control group. Expression of Bax and caspase-9 genes revealed a highly significant increase in cancer cell lines (p = 0.0001) when compared to the control group. In addition to a highly significant decrease (p = 0.005) in Bcl-2 of cancer cells. It was demonstrated that artichoke extract induced cell growth arrest at G2/M phase which revealed a significant increase (p < 0.05) in comparison to the untreated control group.
conclusionArtichoke exerts potent cell cycle arrest, cytotoxic, and apoptotic effects on oral squamous carcinoma cell lines.
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