Evidence map›Paper›PMID 32372386›Full record

ArticleInternational journal of computer assisted radiology and surgery2020

DeepSeg: deep neural network framework for automatic brain tumor segmentation using magnetic resonance FLAIR images.

Ramy A Zeineldin, Mohamed E Karar, Jan Coburger, Christian R Wirtz, Oliver Burgert

Abstract read
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Article in International journal of computer assisted radiology and surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  8. [Research progress of multimodal magnetic resonance imaging brain tumor segmentation based on fused neural network model].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2026
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  11. Clinical evaluation of two glioblastoma delineation methods based on neural networks.Technical innovations & patient support in radiation oncology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ramy A ZeineldinResearch Group Computer Assisted Medicine (CaMed), Reutlingen University, 72762, Reutlingen, Germany. Ramy.Zeineldin@Reutlingen-University.DE.ORCID https://orcid.org/0000-0002-8630-9046
Mohamed E KararFaculty of Electronic Engineering (FEE), Menoufia University, Menouf, 32952, Egypt.ORCID https://orcid.org/0000-0002-0474-4723
Jan CoburgerDepartment of Neurosurgery, University of Ulm, 89312, Günzburg, Germany.ORCID https://orcid.org/0000-0002-3677-8258
Christian R WirtzDepartment of Neurosurgery, University of Ulm, 89312, Günzburg, Germany.ORCID https://orcid.org/0000-0001-8358-1813
Oliver BurgertResearch Group Computer Assisted Medicine (CaMed), Reutlingen University, 72762, Reutlingen, Germany.ORCID http://orcid.org/0000-0001-7118-4730

Funding

Deutscher Akademischer Austauschdienst 91705803
6 · The paper itself

Abstract

purposeGliomas are the most common and aggressive type of brain tumors due to their infiltrative nature and rapid progression. The process of distinguishing tumor boundaries from healthy cells is still a challenging task in the clinical routine. Fluid-attenuated inversion recovery (FLAIR) MRI modality can provide the physician with information about tumor infiltration. Therefore, this paper proposes a new generic deep learning architecture, namely DeepSeg, for fully automated detection and segmentation of the brain lesion using FLAIR MRI data.

methodsThe developed DeepSeg is a modular decoupling framework. It consists of two connected core parts based on an encoding and decoding relationship. The encoder part is a convolutional neural network (CNN) responsible for spatial information extraction. The resulting semantic map is inserted into the decoder part to get the full-resolution probability map. Based on modified U-Net architecture, different CNN models such as residual neural network (ResNet), dense convolutional network (DenseNet), and NASNet have been utilized in this study.

resultsThe proposed deep learning architectures have been successfully tested and evaluated on-line based on MRI datasets of brain tumor segmentation (BraTS 2019) challenge, including s336 cases as training data and 125 cases for validation data. The dice and Hausdorff distance scores of obtained segmentation results are about 0.81 to 0.84 and 9.8 to 19.7 correspondingly.

conclusionThis study showed successful feasibility and comparative performance of applying different deep learning models in a new DeepSeg framework for automated brain tumor segmentation in FLAIR MR images. The proposed DeepSeg is open source and freely available at https://github.com/razeineldin/DeepSeg/.

Indexed as

Deep LearningNeural Networks, ComputerBrain NeoplasmsDisease ProgressionGliomaHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingBrain tumorComputer-aided diagnosisConvolutional neural networksDeep learning

Identifiers

PMID32372386
PMCPMC7303084

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.