Evidence map›Paper›PMID 32372365›Full record

Trial reportAnnals of biomedical engineering2020

Non-Newtonian Effects on Patient-Specific Modeling of Fontan Hemodynamics.

Zhenglun Wei, Shelly Singh-Gryzbon, Phillip M Trusty, Connor Huddleston, Yingnan Zhang, Mark A Fogel, Alessandro Veneziani, Ajit P Yoganathan

Open access · greenAbstract readClinical Trial
In one paragraph

Trial report in Annals of biomedical engineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
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  5. Article
  6. Haemodynamic performance of 16-20-mm extracardiac Goretex conduits in adolescent Fontan patients at rest and during simulated exercise.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2022
    Article
  7. Article
  8. Article
  9. Article
  10. Article
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  12. Article
  13. The Rheology of the Carotid Sinus: A Path Toward Bioinspired Intervention.Frontiers in bioengineering and biotechnology · 2021
    Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Zhenglun WeiWallace H. Coulter School of Biomedical Engineering, Georgia Institute of Technology, 313 Ferst Drive NW, Atlanta, GA, 30332, USA.
Shelly Singh-GryzbonWallace H. Coulter School of Biomedical Engineering, Georgia Institute of Technology, 313 Ferst Drive NW, Atlanta, GA, 30332, USA.
Phillip M TrustyWallace H. Coulter School of Biomedical Engineering, Georgia Institute of Technology, 313 Ferst Drive NW, Atlanta, GA, 30332, USA.
Connor HuddlestonSchool of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA, USA.
Yingnan ZhangWallace H. Coulter School of Biomedical Engineering, Georgia Institute of Technology, 313 Ferst Drive NW, Atlanta, GA, 30332, USA.
Mark A FogelDepartment of Cardiology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Alessandro VenezianiDepartment of Mathematics and Computer Science, Emory, Atlanta, GA, USA.
Ajit P YoganathanWallace H. Coulter School of Biomedical Engineering, Georgia Institute of Technology, 313 Ferst Drive NW, Atlanta, GA, 30332, USA. ajit.yoganathan@bme.gatech.edu.ORCID http://orcid.org/0000-0001-5818-1316
Georgia Institute of Technology · USChildren's Hospital of Philadelphia · USEmory and Henry College · US

Funding

Improving Flow Dynamics in Fontan SurgeriesR01HL067622 · NHLBI · GEORGIA INSTITUTE OF TECHNOLOGY · PI YOGANATHAN, AJIT P · 2002 to 2006
$5.2M
Understanding mechanisms of Fontan failure and key predictors for patient outcomeR01HL098252 · NHLBI · GEORGIA INSTITUTE OF TECHNOLOGY · PI YOGANATHAN, AJIT P · 2010 to 2013
$3.0M
NHLBI NIH HHS HL098252NHLBI NIH HHS HL67622NHLBI NIH HHS R01 HL067622NHLBI NIH HHS R01 HL098252
6 · The paper itself

Abstract

The Fontan procedure is a common palliative surgery for congenital single ventricle patients. In silico and in vitro patient-specific modeling approaches are widely utilized to investigate potential improvements of Fontan hemodynamics that are related to long-term complications. However, there is a lack of consensus regarding the use of non-Newtonian rheology, warranting a systematic investigation. This study conducted in silico patient-specific modeling for twelve Fontan patients, using a Newtonian and a non-Newtonian model for each patient. Differences were quantified by examining clinically relevant metrics: indexed power loss (iPL), indexed viscous dissipation rate (iVDR), hepatic flow distribution (HFD), and regions of low wall shear stress (A

Indexed as

Fontan ProcedureHydrodynamicsModels, CardiovascularPatient-Specific ModelingAdolescentChildFemaleHumansMaleRetrospective StudiesCongenital heart defectsNon-Newtonian rheologyPatient-specific modeling

Identifiers

PMID32372365
PMCPMC7415616
OpenAlexW3021321472

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.