Evidence map›Paper›PMID 32372350›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2020

Design, synthesis, and biological evaluation of novel stachydrine derivatives as potent neuroprotective agents for cerebral ischemic stroke.

Liang Zhang, Feng Li, Chenhui Hou, Sifeng Zhu, Lili Zhong, Jianchun Zhao, Cai Song, Wenbao Li

Abstract read
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In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Liang ZhangSchool of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, China.
Feng LiShandong Peninsula Engineering Research Center of Comprehensive Brine Utilization, Weifang University of Science and Technology, Weifang, 262700, Shandong, People's Republic of China. fengli81@163.com.
Chenhui HouSchool of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, China.
Sifeng ZhuSchool of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, China.
Lili ZhongSchool of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, China.
Jianchun ZhaoSchool of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, China.
Cai SongShenzhen Institute, Guangdong Ocean University, Shenzhen, 518116, China.
Wenbao LiSchool of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, China. wbli92128@ouc.edu.cn.
Ocean University of China · CNGuangdong Ocean University · CNMarine Biomedical Research Institute of Qingdao · CNWeifang University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stachydrine is a natural product with multiple protective biological activities, including those involved in preventing cancer, ischemia, and cardiovascular disease. However, its use has been limited by low bioavailability and unsatisfactory efficacy. To address this problem, a series of stachydrine derivatives (A1/A2/A3/A4/B1/B2/B3/B4) were designed and synthesized, and biological studies were carried out in vitro and in vivo. When compared with stachydrine, Compound B1 exhibited better neuroprotective effects in vitro, and significantly reduced infarction size in the model of the middle cerebral artery occlusion rat model. Therefore, Compound B1 was selected for further research on ischemic stroke. Graphical abstract.

Indexed as

AnimalsAnimals, NewbornBrain IschemiaCells, CulturedCell SurvivalDrug DesignDrug Evaluation, PreclinicalIschemic StrokeNeuroprotective AgentsProlineRatsRats, Sprague-DawleyNeuroprotective AgentsProlinestachydrineBiological activitiesIschemic strokeNeuroprotective agentOrganic synthesisStachydrine derivatives

Identifiers

PMID32372350
OpenAlexW3023464352

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.