Evidence map›Paper›PMID 32372228›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2020

3D PET/CT

Martin Lyngby Lassen, Osamu Manabe, Yuka Otaki, Evann Eisenberg, Phi T Huynh, Frances Wang, Daniel S Berman, Piotr J Slomka

Abstract read
PubMed Publisher
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2025
    Article
  2. Pulmonary blood volume assessment from a standard cardiac rubidium-82 imaging protocol: impact of adenosine-induced hyperemia.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023
    Article
  3. Article
  4. Assessment of a digital and an analog PET/CT system for accurate myocardial perfusion imaging with a flow phantom.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022
    Article
  5. Article
  6. Effects of two patient-specific dosing protocols on measurement of myocardial blood flow with 3DEuropean journal of nuclear medicine and molecular imaging · 2021
    Article
  7. Review
  8. Letter to the editor: Lassen et al. 3D PET/CTEuropean journal of nuclear medicine and molecular imaging · 2020
    Article
  9. Response to the letter to the editor: Lassen et al. 3D PET/CTEuropean journal of nuclear medicine and molecular imaging · 2020
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Martin Lyngby LassenDepartment of Imaging and Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Osamu ManabeDepartment of Imaging and Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Yuka OtakiDepartment of Imaging and Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Evann EisenbergDepartment of Imaging and Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Phi T HuynhDepartment of Imaging and Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Frances WangDepartment of Imaging and Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Daniel S BermanDepartment of Imaging and Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Piotr J SlomkaDepartment of Imaging and Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA. piotr.slomka@cshs.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeQuantification of myocardial blood flow (MBF) has become central in the clinical application of Rubidium-82 (

methodsThis study comprised 20 patients who underwent repeated rest scans in a single imaging session, one employing a full-dose (FD), and the other scan a half-dose (HfD) protocol. Datasets were evaluated for saturation based on visual assessments of input functions and sinograms. We compared FD and HfD MBF measurements using Bland-Altman plots, coefficients of variation (CV), and paired t tests. A correction factor permitting serial analyses using FD/HfD imaging protocols was obtained using only the datasets without saturation.

resultsA dose reduction of 47% was reported for the HfD protocol (FD, 1247 ± 196 MBq; HfD, 662 ± 115 MBq). Saturation effects were observed in 4/20 (20%) FD scans, with none observed in the 20 HfD scans. Assessment of MBFs for FD and HfD protocols revealed bias in the MBF assessments of 0.09 ml/g/min (global MBF, FD = 1.03 ± 0.29 vs HfD = 0.94 ± 0.22 ml/g/min (p = 0.001)). Exclusion of patients with visually identified saturation effects (N = 4) reduced the bias to 0.05 ml/g/min (global MBF, FD = 0.97 ± 0.28 vs HfD = 0.92 ± 0.23 ml/g/min (p = 0.02)). From the datasets without saturation effect, it was possible to generate a bias-correction: Corrected MBF

conclusionSaturation effects can be problematic in

Indexed as

Myocardial Perfusion ImagingPositron Emission Tomography Computed TomographyCoronary CirculationHumansPositron-Emission TomographyReproducibility of ResultsTomography, X-Ray ComputedLow doseMyocardial blood flowPositron emission tomographyRubidium

Identifiers

PMID32372228

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.