ArticleJournal of neurology2020
Lumboperitoneal shunt in idiopathic normal pressure hydrocephalus: a prospective controlled study.
Article in Journal of neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 28 citations in OpenAlex.
- Clinical Outcomes of Lumboperitoneal Shunt Surgery for Normal Pressure Hydrocephalus : A 5-Year Single-Center Retrospective Study of Patients with at Least 1 Year of Follow-Up.Journal of Korean Neurosurgical Society · 2026Article
- Analysis of radiological markers in normal pressure hydrocephalus and their association with postoperative outcomes following shunt procedures.Neurosurgical review · 2026Article
- Minimizing complications in lumboperitoneal shunt for normal pressure hydrocephalus: Technical note and case series.Surgical neurology international · 2026Article
- Long-term outcomes of ventriculoperitoneal shunt therapy in idiopathic normal pressure hydrocephalus.BMC surgery · 2025Article
- Efficacy and safety of idiopathic normal pressure hydrocephalus shunting: a systematic review and meta-analysis.American journal of translational research · 2025Article
- Radiological features of gait phenotypes in patients with idiopathic normal pressure hydrocephalus.Frontiers in aging neuroscience · 2025Article
- Clinical correlates of obstructive sleep apnoea in idiopathic normal pressure hydrocephalus.European journal of neurology · 2024Observational
- The effectiveness of various CSF diversion surgeries in idiopathic normal pressure hydrocephalus: a systematic review and meta-analysis.EClinicalMedicine · 2024Article
- Comparing the Long-Term Cardiovascular Outcomes of Lumbo-Peritoneal, Ventriculo-Peritoneal, or Non-Shunting Treatment after Idiopathic Normal Pressure Hydrocephalus: A Nationwide Retrospective Cohort Study.International journal of medical sciences · 2024Article
- Imaging Markers for Normal Pressure Hydrocephalus: An Overview.Biomedicines · 2023Review
- Longitudinal neuropsychological trajectories in idiopathic normal pressure hydrocephalus: a population-based study.BMC geriatrics · 2023Article
- The Sheep as a Comprehensive Animal Model to Investigate Interdependent Physiological Pressure Propagation and Multiparameter Influence on Cerebrospinal Fluid Dynamics.Frontiers in neuroscience · 2022Article
- One-year outcome of a lumboperitoneal shunt in older adults with idiopathic normal pressure hydrocephalus.Frontiers in surgery · 2022Article
- Dual-Task Performance in Older Adults With and Without Idiopathic Normal Pressure Hydrocephalus.Frontiers in aging neuroscience · 2022Article
- Intraventricular infusion test accuracy in predicting short- and long-term outcome of iNPH patients: a 10-year update of a three-decade experience at a single institution.Neurosurgical review · 2021Article
- Clinical Outcome and Striatal Dopaminergic Function After Shunt Surgery in Patients With Idiopathic Normal Pressure Hydrocephalus.Neurology · 2021Article
- Dynamic functional networks in idiopathic normal pressure hydrocephalus: Alterations and reversibility by CSF tap test.Human brain mapping · 2021Article
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 4 countries.
Funding
Abstract
objectiveIn this prospective, controlled, monocentric study, we described the clinical and neuroimaging 12-month follow-up of two parallel cohorts of subjects with idiopathic normal pressure hydrocephalus (iNPH), who did or did not undergo lumboperitoneal shunt (LPS).
methodsWe recruited 78 iNPH patients. At baseline, subjects underwent clinical and neuropsychological assessments, 3 T magnetic resonance imaging (MRI), and tap test. After baseline, 44 patients (LPS group) opted for LPS implantation, whereas 34 subjects (control group) declined surgery. Both cohorts were then followed up for 12 months through scheduled clinical and neuropsychological evaluations every 6 months. 3 T MRI was repeated at 12-month follow-up.
resultsGait, balance, and urinary continence improved in the LPS group, without significant influence on cognitive functions. Conversely, gait and urinary continence worsened in the control group. No preoperative MRI parameter was significant outcome predictor after LPS. Of relevance, in responders to LPS, we found postoperative reduction of periventricular white matter (PWM) hyperintensities, which were instead increased in the control group.
conclusionsLPS is safe and effective in iNPH. An early surgical treatment is desirable to prevent clinical worsening. Post-surgery decrease of PWM hyperintensities may be a useful MRI marker surrogate for clinical effectiveness of LPS.
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