Evidence map›Paper›PMID 32372033›Full record

ReviewNature reviews. Neurology2020

Treatment and management of cognitive dysfunction in patients with multiple sclerosis.

John DeLuca, Nancy D Chiaravalloti, Brian M Sandroff

2 registry-linked trialsAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 93 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed, 4 pooled it
16.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06436131 nacompletednot on this mapstarted 2023, after this paper: background citation

The Effects of In-phase Bilateral Exercise on Cognitive and Motor Outcome Measures, in Patients with Progressive Multiple Sclerosis, a Randomized Control Trial.

TypeinterventionalSponsorCyprus University of TechnologyRan2023 to 2023Enrolled20ConditionsMultiple Sclerosis, Primary Progressive, Multiple Sclerosis, Secondary ProgressiveArmsIn-phase Bilateral Exercise, Conservative exercises
NCT07355387 narecruitingnot on this mapstarted 2025, after this paper: background citation

Home Based Functional Balance Intervention (FBI) for Physical and Cognitive Symptoms of Multiple Sclerosis

TypeinterventionalSponsorUniversity of Illinois at ChicagoRan2025 to 2027Enrolled75ConditionsMultiple Sclerosis, Multiple Sclerosis (MS) - Relapsing-remitting, Multiple Sclerosis (MS) Primary Progressive, Multiple Sclerosis (MS) Secondary ProgressiveArmsMulticomponent balance intervention consisting of four components including dual-tasking, functional strength, vestibular and dynamic balance., Stretching
3 · Its place in the literature

Who cites it

93 citing papers in PubMed, 4 syntheses or guidelines pooled it, 198 citations in OpenAlex.

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33 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

John DeLucaKessler Foundation, East Hanover, NJ, USA. jdeluca@kesslerfoundation.org.ORCID 0000-0003-3745-4156
Nancy D ChiaravallotiKessler Foundation, East Hanover, NJ, USA.ORCID 0000-0003-2943-7567
Brian M SandroffDepartment of Physical Therapy, University of Alabama at Birmingham, Birmingham, AL, USA.
Kessler Foundation · USUniversity of Alabama at Birmingham · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cognitive impairment is a common and devastating manifestation of multiple sclerosis (MS). Although disease-modifying therapies have been efficacious for reducing relapse rates in MS, such treatments are ineffective for treating cognitive dysfunction. Alternative treatment approaches for mitigating cognitive problems are greatly needed in this population. To date, cognitive rehabilitation and exercise training have been identified as possible candidates for treating MS-related cognitive impairment; however, cognitive dysfunction is still often considered to be poorly managed in patients with MS. This Review provides a comprehensive overview of recent developments in the treatment and management of cognitive impairment in people with MS. We describe the theoretical rationales, current states of the science, field-wide challenges and recent advances in cognitive rehabilitation and exercise training for treating MS-related cognitive impairment. We also discuss future directions for research into the treatment of cognitive impairment in MS that should set the stage for the inclusion of cognitive rehabilitation and exercise training into clinical practice within the next decade.

Indexed as

Disease ManagementCognitive Behavioral TherapyCognitive DysfunctionHumansMultiple SclerosisNeuropsychological TestsTherapy, Computer-AssistedTreatment Outcome

Identifiers

PMID32372033
OpenAlexW3020894047

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.