Evidence map›Paper›PMID 32372032›Full record

ArticleScientific reports2020

Development of a new macrophage-specific TRAP mouse (Mac

Andreas Hofmeister, Maximilian C Thomaßen, Sabrina Markert, André Marquardt, Mathieu Preußner, Martin Rußwurm, Ralph T Schermuly, Ulrich Steinhoff, Hermann-Josef Gröne, Joachim Hoyer and 2 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 2 countries.

Andreas HofmeisterDepartment of Internal Medicine and Nephrology, University Hospital Giessen and Marburg, Philipps-University, Marburg, Germany.
Maximilian C ThomaßenDepartment of Internal Medicine and Nephrology, University Hospital Giessen and Marburg, Philipps-University, Marburg, Germany.
Sabrina MarkertDepartment of Internal Medicine and Nephrology, University Hospital Giessen and Marburg, Philipps-University, Marburg, Germany.
André MarquardtInstitute of Pathology, Julius-Maximilians-University Würzburg and Comprehensive Cancer Center Mainfranken, Würzburg, Germany.
Mathieu PreußnerDepartment of Internal Medicine and Nephrology, University Hospital Giessen and Marburg, Philipps-University, Marburg, Germany.
Martin RußwurmDepartment of Internal Medicine and Nephrology, University Hospital Giessen and Marburg, Philipps-University, Marburg, Germany.
Ralph T SchermulyDepartment of Internal Medicine, Universities of Giessen and Marburg Lung Center, Giessen, Germany.
Ulrich SteinhoffInstitute for Medical Microbiology and Hygiene, Philipps-University, Marburg, Germany.
Hermann-Josef GröneInstitute of Pharmacology, Philipps-University, Marburg, Germany.
Joachim HoyerDepartment of Internal Medicine and Nephrology, University Hospital Giessen and Marburg, Philipps-University, Marburg, Germany.
Benjamin D HumphreysDivision of Nephrology, Department of Medicine, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.
Ivica GrgicDepartment of Internal Medicine and Nephrology, University Hospital Giessen and Marburg, Philipps-University, Marburg, Germany. grgic@med.uni-marburg.de.
Universitätsklinikum Gießen und Marburg · DEComprehensive Cancer Center Mainfranken · DEInstitute of Medical Microbiology and Hygiene · DEPhilipps University of Marburg · DEUniversities of Giessen and Marburg Lung Center · DEWashington University in St. Louis · US

Funding

Hedgehog Signaling in Kidney Homeostasis and RepairR01DK088923 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI HUMPHREYS, BENJAMIN D. · 2010 to 2014
$2.0M
Kidney pericytes in vascular regeneration after injuryRC1DK087389 · NIDDK · UNIVERSITY OF WASHINGTON · PI DUFFIELD, JEREMY S · 2009 to 2010
$989k
NIDDK NIH HHS R01 DK088923NIDDK NIH HHS RC1 DK087389
6 · The paper itself

Abstract

Tissue macrophages play an important role in organ homeostasis, immunity and the pathogenesis of various inflammation-driven diseases. One major challenge has been to selectively study resident macrophages in highly heterogeneous organs such as kidney. To address this problem, we adopted a Translational Ribosome Affinity Purification (TRAP)- approach and designed a transgene that expresses an eGFP-tagged ribosomal protein (L10a) under the control of the macrophage-specific c-fms promoter to generate c-fms-eGFP-L10a transgenic mice (Mac

Indexed as

Genetic TechniquesProtein BiosynthesisAnimalsDendritic CellsGene Expression ProfilingGreen Fluorescent ProteinsImmunohistochemistryInflammationKidneyMacrophagesMiceMice, TransgenicRibosomesRNARNA-SeqTransgenesGreen Fluorescent ProteinsRNA

Identifiers

PMID32372032
PMCPMC7200716
OpenAlexW3021188148

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.