ArticleNature communications2020
Segregation of an MSH1 RNAi transgene produces heritable non-genetic memory in association with methylome reprogramming.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 72 citations in OpenAlex.
- Advances in the study of the role of epigenetic mechanisms in plant growth and response to stress.Horticulture research · 2026Article
- Short days, long memories: plastid-to-nucleus signaling links photoperiod to heritable epigenetic change.Plant physiology · 2026Article
- Intragenic methylation repatterning is associated with alternative splicing and unique epigenetic phenotypes.bioRxiv : the preprint server for biology · 2026Article
- Long-distance transport of siRNAs with functional roles in pollen development.Nature plants · 2026Article
- Intragenic methylation repatterning is associated with alternative splicing and unique epigenetic phenotypes.Environmental epigenetics · 2026Article
- Epigenetic crop improvement: Integrating ENCODE strategies into horticultural breeding.Horticulture research · 2025Article
- Gaining insights into epigenetic memories through artificial intelligence and omics science in plants.Journal of integrative plant biology · 2025Review
- Expansion of the MutS gene family in plants.The Plant cell · 2025Article
- Unravelling the Epigenetic Code: DNA Methylation in Plants and Its Role in Stress Response.Epigenomes · 2024Review
- Expansion of the MutS Gene Family in Plants.bioRxiv : the preprint server for biology · 2024Article
- Plant Organellar MSH1 Is a Displacement Loop-Specific Endonuclease.Plant & cell physiology · 2024Article
- Phenotypic plasticity for improved light harvesting, in tandem with methylome repatterning in reef-building corals.Molecular ecology · 2024Article
- Sensory plastid-associated PsbP DOMAIN-CONTAINING PROTEIN 3 triggers plant growth- and defense-related epigenetic responses.The Plant journal : for cell and molecular biology · 2023Article
- On the thermodynamics of DNA methylation process.Scientific reports · 2023Article
- Epigenetic Changes Occurring in Plant Inbreeding.International journal of molecular sciences · 2023Review
- Plant environmental sensing relies on specialized plastids.Journal of experimental botany · 2022Review
- Remember the time.Physiologia plantarum · 2022Article
- Methylome decoding of RdDM-mediated reprogramming effects in the Arabidopsis MSH1 system.Genome biology · 2022Article
- Integrate Small RNA and Degradome Sequencing to Reveal Drought Memory Response in Wheat (International journal of molecular sciences · 2022Article
- The Barley Chloroplast Mutator (International journal of molecular sciences · 2022Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
MSH1 is a plant-specific protein. RNAi suppression of MSH1 results in phenotype variability for developmental and stress response pathways. Segregation of the RNAi transgene produces non-genetic msh1 'memory' with multi-generational inheritance. First-generation memory versus non-memory comparison, and six-generation inheritance studies, identifies gene-associated, heritable methylation repatterning. Genome-wide methylome analysis integrated with RNAseq and network-based enrichment studies identifies altered circadian clock networks, and phytohormone and stress response pathways that intersect with circadian control. A total of 373 differentially methylated loci comprising these networks are sufficient to discriminate memory from nonmemory full sibs. Methylation inhibitor 5-azacytidine diminishes the differences between memory and wild type for growth, gene expression and methylation patterning. The msh1 reprogramming is dependent on functional HISTONE DEACETYLASE 6 and methyltransferase MET1, and transition to memory requires the RNA-directed DNA methylation pathway. This system of phenotypic plasticity may serve as a potent model for defining accelerated plant adaptation during environmental change.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.