Evidence map›Paper›PMID 32371664›Full record

ArticleJournal of the Chinese Medical Association : JCMA2020

Penumbra volume predicts unfavorable outcome in patients with acute minor stroke or transient ischemic attack.

Chih-Hsiang Liao, Nien-Chen Liao, Wen-Hsien Chen, Hung-Chieh Chen, Ming-Hong Chang, Yuang-Seng Tsuei, Chiung-Chyi Shen, Shun-Fa Yang, Po-Lin Chen

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the Chinese Medical Association : JCMA, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 2 pooled it
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 syntheses or guidelines pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Chih-Hsiang LiaoInstitute of Medicine, Chung Shan Medical University, Taichung, Taiwan, ROC.
Nien-Chen LiaoDivision of General Neurology, Neurological Institute, Taichung Veterans General Hospital, Taichung, Taiwan, ROC.
Wen-Hsien ChenDivision of Neuro-radiology, Department of Radiology, Taichung Veterans General Hospital, Taichung, Taiwan, ROC.
Hung-Chieh ChenDivision of Neuro-radiology, Department of Radiology, Taichung Veterans General Hospital, Taichung, Taiwan, ROC.
Ming-Hong ChangInstitute of Medicine, Chung Shan Medical University, Taichung, Taiwan, ROC.
Yuang-Seng TsueiInstitute of Medicine, Chung Shan Medical University, Taichung, Taiwan, ROC.
Chiung-Chyi ShenDivision of Neurosurgery, Neurological Institute, Taichung Veterans General Hospital, Taichung, Taiwan, ROC.
Shun-Fa YangInstitute of Medicine, Chung Shan Medical University, Taichung, Taiwan, ROC.
Po-Lin ChenDivision of General Neurology, Neurological Institute, Taichung Veterans General Hospital, Taichung, Taiwan, ROC.
Taichung Veterans General Hospital · TWChung Shan Medical University · TWChung Shan Medical University Hospital · TWNational Yang Ming Chiao Tung University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA subgroup of patients with acute minor stroke (AMS) or transient ischemic attack (TIA) become disabled due to disease progression (DP) or recurrent stroke within 3 months. The aim of this article is to identify the risk factors for DP in AMS/TIA patients. In the literature, no studies focused on computed tomography perfusion (CTP) in AMS/TIA patients at the acute stage.

methodsThis retrospective study included patients with AMS or TIA (onset of symptoms ≤4.5 hours, baseline National Institutes of Health Stroke Scale [NIHSS] score of 0-4). DP was defined as a deterioration of NIHSS score of ≥2 points during hospitalization or modified Ranking Scale ≥2 at 3-month follow-up. Clinical data and imaging results were retrieved and measured for statistical analysis.

resultsFrom 2011 to 2017, total 135 patients were eligible for further analysis: 28 patients (20.7%, DP group) and 107 patients (79.3%, non-DP group). The DP group had significantly higher larger penumbra volumes (p = 0.028). In univariate model of the logistic regression, patients with the following risk factors tended to have unfavorable outcome: female gender, higher HbA1c, chronic kidney disease stage ≥3b, intracranial atherosclerosis, and penumbra volume were associated unfavorable outcome, but larger deadcore volume was not. In further multivariate analysis, only penumbra volume >5 cm (p = 0.049, odds ratio [OR] = 3.21, 95% CI: 1.00-10.27) had the statistical significance. The cut-point value of the penumbra volume for unfavorable outcome in AMS/TIA patients was 4.73 cm.

conclusionOne fifth of the AMS/TIA patients had unfavorable outcome at 90 days. In CTP performed within 4.5 hours after the onset of AMS/TIA, the penumbra volume (>5 cm) was a significant risk factor for DP, and the cut-point value was 4.73 cm. Further studies could be designed to involve this subgroup of patients for more aggressive treatment.

Indexed as

AgedComputed Tomography AngiographyDisease ProgressionFemaleHumansIschemic Attack, TransientMaleMiddle AgedPerfusion ImagingRecurrenceRetrospective StudiesRisk FactorsStroke

Identifiers

PMID32371664
PMCPMC12999162
OpenAlexW3020834664

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.