Evidence map›Paper›PMID 32371604›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2020

Disruption of

Eliot T Smith, Itallia Pacentine, Anna Shipman, Matthew Hill, Teresa Nicolson

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.5field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. The Role of Calcium Signaling in Sensorineural Hearing Loss.International journal of medical sciences · 2025
    Review
  8. Defects in Exosome Biogenesis Are Associated with Sensorimotor Defects in ZebrafishThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Transmembrane Channel-Like (Tmc) Subunits Contribute to Frequency Sensitivity in the Zebrafish Utricle.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  15. Article
  16. Article
  17. Article
  18. Vestibular physiology and function in zebrafish.Frontiers in cell and developmental biology · 2023
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Eliot T SmithDepartment of Otolaryngology Head and Neck Surgery, Stanford School of Medicine, Stanford University, Stanford, California 94305.
Itallia PacentineOregon Hearing Research Center, Oregon Health and Science University, Portland, Oregon 97239.ORCID 0000-0002-3041-7937
Anna ShipmanDepartment of Otolaryngology Head and Neck Surgery, Stanford School of Medicine, Stanford University, Stanford, California 94305.
Matthew HillOregon Hearing Research Center, Oregon Health and Science University, Portland, Oregon 97239.
Teresa NicolsonDepartment of Otolaryngology Head and Neck Surgery, Stanford School of Medicine, Stanford University, Stanford, California 94305 tnicolso@stanford.edu.
Stanford Medicine · USOregon Health & Science University · US

Funding

Molecular Analysis of Tmie in sensory hair cellsR01DC017046 · NIDCD · STANFORD UNIVERSITY · PI NICOLSON, TERESA A · 2018 to 2022
$1.7M
Characterization of the Mechanotransduction complex in hair cellsR01DC013572 · NIDCD · STANFORD UNIVERSITY · PI NICOLSON, TERESA A · 2015 to 2019
$1.6M
In vivo biotinylation for analysis of nuclear and protein dynamicsR01DC013531 · NIDCD · OREGON HEALTH & SCIENCE UNIVERSITY · PI NICOLSON, TERESA A · 2013 to 2017
$1.2M
NIDCD NIH HHS R01 DC013531NIDCD NIH HHS R01 DC013572NIDCD NIH HHS R01 DC017046
6 · The paper itself

Abstract

Detection of sound and head movement requires mechanoelectrical transduction (MET) channels at tips of hair-cell stereocilia. In vertebrates, the transmembrane channel-like (TMC) proteins TMC1 and TMC2 fulfill critical roles in MET, and substantial evidence implicates these TMCs as subunits of the MET channel. To identify developmental and functional roles of this Tmc subfamily in the zebrafish inner ear, we tested the effects of truncating mutations in

Indexed as

Acoustic StimulationAnimalsAnimals, Genetically ModifiedHair Cells, Auditory, InnerHearingMechanotransduction, CellularMembrane ProteinsZebrafishZebrafish ProteinsMembrane ProteinsTMC1 protein, zebrafishTMC2a protein, zebrafishTmc2b protein, zebrafishZebrafish Proteinsauditory/vestibular systemhair cellsinner earmechanoelectrical transductionmechanosensationTMC proteins

Identifiers

PMID32371604
PMCPMC7275854
OpenAlexW3021442277

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.