Evidence map›Paper›PMID 32371596›Full record

ReviewmBio2020

Threats Posed by the Fungal Kingdom to Humans, Wildlife, and Agriculture.

Matthew C Fisher, Sarah J Gurr, Christina A Cuomo, David S Blehert, Hailing Jin, Eva H Stukenbrock, Jason E Stajich, Regine Kahmann, Charles Boone, David W Denning and 9 more

Open access · goldAbstract readReview
In one paragraph

Review in mBio, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 277 papers.

0numbers the graph read from it
0cells of the map it votes in
277citing papers in PubMed
66.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

277 citing papers in PubMed, 521 citations in OpenAlex.

  1. Review
  2. The Origin and Early Evolution of Fungi: Challenges, Inferences, and Principles.Annual review of cell and developmental biology · 2026
    Review
  3. Biomolecules · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Early Cellular Responses ofAntibiotics (Basel, Switzerland) · 2026
    Article
  8. Article
  9. Article
  10. Drivers of bat researchers' intent to adopt field hygiene practices.Conservation biology : the journal of the Society for Conservation Biology · 2026
    Article
  11. Article
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  14. Article
  15. Article
  16. Article
  17. Article
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  19. Article
  20. Article

217 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 16 institutions in 5 countries.

Matthew C FisherMRC Centre for Global Infectious Disease Analysis, Imperial College, London, United Kingdom.ORCID 0000-0002-1862-6402
Sarah J GurrDepartment of Biosciences, University of Exeter, Exeter, United Kingdom.
Christina A CuomoInfectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.ORCID 0000-0002-5778-960X
David S BlehertU.S. Geological Survey, National Wildlife Health Center, Madison, Wisconsin, USA.
Hailing JinDepartment of Microbiology and Plant Pathology, Center for Plant Cell Biology, Institute for Integrative Genome Biology, University of California-Riverside, Riverside, California, USA.
Eva H StukenbrockMax Planck Fellow Group Environmental Genomics, Max Planck Institute for Evolutionary Biology, Plön, Germany.
Jason E StajichDepartment of Microbiology and Plant Pathology, Center for Plant Cell Biology, Institute for Integrative Genome Biology, University of California-Riverside, Riverside, California, USA.ORCID 0000-0002-7591-0020
Regine KahmannMax Planck Institute for Terrestrial Microbiology, Department of Organismic Interactions, Marburg, Germany.
Charles BooneDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
David W DenningThe National Aspergillosis Centre, Wythenshawe Hospital, The University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom.
Neil A R GowDepartment of Biosciences, University of Exeter, Exeter, United Kingdom.ORCID 0000-0002-2776-5850
Bruce S KleinDepartment of Pediatrics, Department of Internal Medicine, and Department of Medical Microbiology and Immunology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.
James W KronstadMichael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada.ORCID 0000-0003-4240-6976
Donald C SheppardMcGill Interdisciplinary Initiative in Infection and Immunology, Departments of Medicine, Microbiology & Immunology, McGill University, Montreal, Canada.
John W TaylorUniversity of California-Berkeley, Department of Plant and Microbial Biology, Berkeley, California, USA.
Gerard D WrightM.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada.
Joseph HeitmanDepartment of Molecular Genetics and Microbiology, Medicine, and Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina, USA.
Arturo CasadevallDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.ORCID 0000-0002-9402-9167
Leah E CowenDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada leah.cowen@utoronto.ca.
University of California, Riverside · USUniversity of Exeter · GBUniversity of Toronto · CABroad Institute · USChristian-Albrechts-Universität zu Kiel · DEDuke University · USImperial College London · GBJohns Hopkins University · USManchester Academic Health Science Centre · GBMax Planck Institute for Terrestrial Microbiology · DEMcGill University · CAMcMaster University · CAUnited States Geological Survey · USUniversity of British Columbia · CAUniversity of California, Berkeley · USUniversity of Wisconsin–Madison · US

Funding

PROTECTIVE IMMUNE RESPONSES TO BLASTOMYCES DERMATITIDISR01AI040996 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI KLEIN, BRUCE STEVEN, WUETHRICH, MARCEL · 1997 to 2023
$10.4M
Structure, function, and evolution of the Cryptococcus MAT locusR01AI050113 · NIAID · DUKE UNIVERSITY · PI HEITMAN, JOSEPH · 2002 to 2024
$8.5M
Synergy of Host Defense Mechanisms in the LungR01HL059842 · NHLBI · YESHIVA UNIVERSITY · PI CASADEVALL, ARTURO · 1997 to 2023
$7.4M
Molecular Pathogenesis of BlastomycosisR37AI035681 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI BRUCE Steven KLEIN · 2004 to 2026
$6.9M
ROLE OF CALCINEURIN IN C. NEOFORMANS MATING AND FRUITINGR01AI039115 · NIAID · DUKE UNIVERSITY · PI HEITMAN, JOSEPH · 1997 to 2025
$6.7M
Genetics of Cryptococcus sexual reproductionR37AI039115 · NIAID · DUKE UNIVERSITY · PI HEITMAN, JOSEPH · 2011 to 2020
$4.9M
Lung epithelial cell regulation of immunity to inhaled fungiR01AI130411 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI KLEIN, BRUCE STEVEN · 2018 to 2021
$2.0M
Medical Research Council MR/N006364/2Medical Research Council MR/R015600/1NHLBI NIH HHS R01 HL059842NIAID NIH HHS R01 AI039115NIAID NIH HHS R01 AI040996NIAID NIH HHS R01 AI050113NIAID NIH HHS R01 AI130411NIAID NIH HHS R37 AI035681NIAID NIH HHS R37 AI039115
6 · The paper itself

Abstract

The fungal kingdom includes at least 6 million eukaryotic species and is remarkable with respect to its profound impact on global health, biodiversity, ecology, agriculture, manufacturing, and biomedical research. Approximately 625 fungal species have been reported to infect vertebrates, 200 of which can be human associated, either as commensals and members of our microbiome or as pathogens that cause infectious diseases. These organisms pose a growing threat to human health with the global increase in the incidence of invasive fungal infections, prevalence of fungal allergy, and the evolution of fungal pathogens resistant to some or all current classes of antifungals. More broadly, there has been an unprecedented and worldwide emergence of fungal pathogens affecting animal and plant biodiversity. Approximately 8,000 species of fungi and Oomycetes are associated with plant disease. Indeed, across agriculture, such fungal diseases of plants include new devastating epidemics of trees and jeopardize food security worldwide by causing epidemics in staple and commodity crops that feed billions. Further, ingestion of mycotoxins contributes to ill health and causes cancer. Coordinated international research efforts, enhanced technology translation, and greater policy outreach by scientists are needed to more fully understand the biology and drivers that underlie the emergence of fungal diseases and to mitigate against their impacts. Here, we focus on poignant examples of emerging fungal threats in each of three areas: human health, wildlife biodiversity, and food security.

Indexed as

AgricultureAnimalsAnimals, WildFungiGlobal HealthHumansMycosesPlant DiseasesPlantsantifungal resistancebiodiversityfood securityfungal pathogensglobal healthmedical mycologyplant-pathogenic fungiwildlife pathogens

Identifiers

PMID32371596
PMCPMC7403777
OpenAlexW3023175438

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.